Final 20

Question 1

Type 1 rapid hypersensitivity

Answer 1

Atopic allergy. 
Most common 
IeG antibody class 
Anaphylaxis 
Allergic asthma
Allergies to specific antigens

Question 2

Type 2: cytotoxic

Answer 2

Reaction of IgAntibody made by immune system

Directed against one or more of individuals own proteins

Question 3

Allergic rhinitis

Answer 3

Hay fever 
Airborne allergens 
Plant 
Mild
Dust
Animal
Wool
Food
Pollution

Question 4

First exposure to allergen

Answer 4

IeG binds to surface of basophils and mast cells
These cells have vasoactive amines (histamines)
Once this happens, person is sensitized to that allergen

Question 5

Elevated lymphocytes

Answer 5

Viral

Question 6

Elevated neutrophils

Answer 6

Bacterial

Question 7

Eosinophils

Answer 7

1-2%

Question 8

Patch test

Answer 8

Reserved for contact dermatitis

Question 9

Food diary

Answer 9

If skin testing is not conclusive, then do a food diary

Question 10

IgE

Answer 10

<100

Question 11

Decongestants

Answer 11

Cause vasoconstriction of inflamed tissue, reducing EDEMA
No glaucoma
No urinary retention
No hypertension

Question 12

Decongestant example

Answer 12

Sudafed

Question 13

Antihistamine

Answer 13

Block histamine from binding to receptor

Prevents vasodilation and capillary leak

Question 14

Antihistamine examples

Answer 14

Benadryl
Claritin
Zyrtec
Allegra

Question 15

Corticosteroids

Answer 15

Decrease inflammation

Prevent synthesis of mediators

Question 16

Mast cell stabilizing drugs

Answer 16

Prevent mast cell from opening when an alllergen binds to IgE

Nasalcrom

Question 17

Leukotriene anatagonist

Answer 17

Manage and prevent rhinitis

Singular

Question 18

Desensitization therapy

Answer 18

Allergy shots

Cannot be avoided

Question 19

Penicillin allergy

Answer 19

Cephalosporin allergy?

Question 20

Banana or avocado allergy

Answer 20

Latex allergy?

Question 21

Examples of type 2

Answer 21

Immune hemolytic Anemia
Immune thrombocytopenia outputs
Hemolytic transfusion reaction 
Goodpastures syndrome 
Drug induced hemolytic anemia

Question 22

Plasmapheresis

Answer 22

Filtration of the plasma to remove specific substances

Question 23

Type 3 immune complex reactions

Answer 23

Formation of large and small immune complexes
Lupus
RA

Question 24

Circulating complexes usually lodge in

Answer 24

Kidneys
Skin
Joints
Small blood vessels

Question 25

RA

Answer 25

Type 3
Immunicomplexes lodge in joint spaces
Scarring
Fibrous changes 
Tissue destruction

Question 26

Lupus

Answer 26

Immune complexes lodge in vessels causing vasculitis
Glomeruli
Arthritis

Question 27

Type 4

Answer 27

Sensitized T cell from previous exposure
Release chemical mediators and macrophages
Hours to days

Question 28

Type 4 example

Answer 28

TB test 
Poison ivy
Contact dermatitis 
Tissue transplant rejections
Sarcoidosis

Question 29

Lupus clinical manifestations

Answer 29

Butterfly rash 
Polyarthritis
Osteonectrosis
Muscle atrophy 
Fever fatigue 
Renal
Pleural effusion 
Pericarditis
Raynaud's phenomenon 
Abdominal pain
Neurological manifestation

Question 30

SLE

Answer 30

Chronic progressive inflammatory connective tissue disorder- major organ failure
Exacerbation

Question 31

SLE patho

Answer 31

Complexes invade organs directly or cause vasculitis, cutting off O2 supply
—–kidneys——

Question 32

DLE

Answer 32

Affects skin only

Question 33

SLE PLaquenil

Answer 33

Decreased absorption of UV light.
Skin lesions
Frequent eye exams

Question 34

SLE chronic steroid treatment

Answer 34

Methotrexate

Azathioprine

Question 35

SLE first drug approved in 60 years

Answer 35

Belimumab (benlysta)