test 1.1 Flashcards
what is the purpose of the inflammation process
to deliver defensive materials (blood cells and fluid) to a site of injury
what is the three basic problems caused by injury
- Pain 2. Swelling 3. Loss of function
which of the following; Neutrophils, marcophages, platelets, endothelium, mast cells, fibroblast is responsible for Leukocyte typical of acute inflammation;
first line of defense against bacteria
neutrophils
which of the following; Neutrophils, marcophages, platelets, endothelium, mast cells, fibroblast is responsible for Leukocyte key of chronic inflammation;
synthesize dozen of mediators
marcophages
which of the following; Neutrophils, marcophages, platelets, endothelium, mast cells, fibroblast is responsible for Key role in blood clotting
platelets
which of the following; Neutrophils, marcophages, platelets, endothelium, mast cells, fibroblast is responsible for Mediates the exchange of fluid and cells
endothelium
which of the following; Neutrophils, marcophages, platelets, endothelium, mast cells, fibroblast is responsible for Consist of chemical mediators
mast cells
which of the following; Neutrophils, marcophages, platelets, endothelium, mast cells, fibroblast is responsible for Intervene during healing; make collegen, myofibroblasts, plasma
fibroblast
what is the lifespan of neutrophils
12-20 hours
what is the second line of defense and it lives for months
marcophages
what are the three types of chemical mediators
- Vasodilation 2. Increased vascular permeability 3. Pain
true or false
Vascular Changes involves changes in the microvascular structures that involves alterations in blood flow and endothelial permeability
and Promote fluid and cellular accumulation at the site of injury
true
does Vasodilation slow or speed the rate of blood flood to affected areas
slows it down
true or false
All cells have the same roles associated with inflammation
false
they all have definitive roles associated with inflammation
true or false
Vascular injury induces hemostasis causing platelets to become active
true
what is the sequence of leukocyte emigration
• Endothelial cell activation • Leukocyte margination • Leukocyte rolling • Leukocyte adhesion • Leukocyte extravasation • Chemotaxis • Leukocyte activation • Phagocytosis and digestion
true or false
Various inflammatory mediators activate endothelial cells
true
what are the characteristics of neutrophils
- Hallmark of acute inflammation
- First to begin defensive response and “process”
- Die within 24hrs
- Phagocytize and digest (address bacterial infection)
what is the half life for macrophages
months
what are the functions of marcophages
- Proinflammatory
- Phagocytic (address debris) 3. Release growth factors for stimulating repair and
regeneration
what do mediators do in response to the inflammation process
- Plasma and cell derived mediators regulate inflammation
- Mediators bind to specific receptors and induce a cell response
- Mediator’s effect is cell dependent
what are three systems that are plasma dervied inflammatory mediators
•Kinin system
•Clotting System
–Hageman Factor (XII)
•Complement System
what does the Kinin system do
- Activated by Hageman factor XII
- Increases vascular permeability
- Stimulates nociceptors
what does the clotting system do
- Extrinsic system of tissue factor and factor VII
- Creates fibrin clot and scaffold for arriving cells
- Releases histamin
what does the complement system do
•Increase phagocytosis •Increase general inflammatory response •Increase vascular permeability •Increase concentration of chemotactic
attraction for WBC (leukocyte
what are the outcomes of acute inflammation
- Resolution
- Abscess formation (bacterial infection)
- Fibrosis
- Chronic Inflammation
what is the difference between chronic inflammation and acute inflammation
- Macrophages predominate 2. Additional infiltration of fibroblasts
- Abundance of stimulating chemicals
