Test 1: 6 phenothiazine Flashcards
what are two antipsychotic/tranquilizer meds
phenothiazine- acepromazine
butyrophenones- azaperone
— are D2 antagonists
Phenothiazines- Acepromazine
Butyrophenones- Azaperone
why is acepromazine not used as anti-physcotic anymore
does not stops the impulse, just makes the body that it can’t do it
azepromazine works on what receptor
post synaptic D2 antagonist
where are the antidopaminergic effects of phenothiazine and butyrophenones
Cerebral cortex- EEG abnormalities/seizures
basal ganglia
limbic system
hypothalamus/pituitary- impaired thermoregulation
brainstem- impaired vasomotor reflexes
medulla- CTZ- protect against nausea
ace is a non reversible sedative
Phenothiazines- Acepromazine
Butyrophenones- Azaperone
what are the non dopaminergic effects of phenothiazine and butyrophenones
autonomic nervous system
- antimuscarinic (M1 receptors)
- antiadrenergic (α1 and α2 receptors) (Hypotension)
- antihistaminergic (H1 receptors)
- antiserotoninergic (5HT2A/2C)
Phenothiazines- Acepromazine
Butyrophenones- Azaperone
side effects of azepromazine
sedation (D2 antagonist)
hypotension (antiadrenergic a1 and a2 receptors)
spleen also gets big and antihistamine effect
withdrawal times for acepromazine
milk withdrawal: 48 hours
meat withdrawal: 7 days
why is acepromazine not used in adult horses
causes priapism (erections)
MAC reduction for acepromazine
30-45% (very good compared to other drugs)
reduces the amount of inhalant drugs needed to keep pt under
complications of acepromazine on CNS
Inconsistent calming
Orthostatic hypotension
Extrapyramidal side-effects (anti-dopaminergic)
* Diphenhydramine to treat
complications of acepromazine on hematologic system
↓HCT by 20-50% in dogs or horses from splenic sequestration
if giving an allergy test what sedative should you not use
acepromazine
has an antihistaminergic effect
