Teratogens/ side effects of drugs

Question 1

Red man syndrome

Answer 1

Vancomycin

Question 2

Grey baby syndrome

Answer 2

Chloramphenicol

Question 3

Nephrotoxicity especially with cephalosporins

Answer 3

Aminoglycosides

Question 4

Fetal renal damage if used during pregnancy

Answer 4

-ARBs/ ACE inhibitors

Question 5

Absence of digits, multiple anomalies during pregnancy

Answer 5

Alkylating agents

Question 6

CN 8 toxicity

Answer 6

Aminoglycosides

Question 7

Facial dysmorphism, developmental delay, neural tube defects, phalanx/fingernail hypoplasia

Answer 7

Carbamazepine

Question 8

Vaginal clear cell adenocarcinoma, congenital mullerian anomalies

Answer 8

Diethylstilbestrol (DES)

Question 9

Folate antagonists??

What is their side effect during pregnancy?

Answer 9

5-FU
Methletrexate
Valproic acid

Inhibit mother’s folate absorption —> neural tube defect

Question 10

Isotretinoin causes?

Answer 10

multiple severe birth defects. Contraception is mandatory

Question 11

Ebstein anomaly

Answer 11

Lithium

Question 12

Aplasia cutis congeita

Answer 12

Methimazole

Question 13

What is Fetal hydantoin syndrome ? who causes it?

Answer 13

cleft palate, cardiac defects, phalanx/fingernail aplasia

Phenytoin

Question 14

Tetracyclines

Answer 14

discolored teeth

Question 15

Warfarin

Answer 15

bone deformities, fetal hemorrhage, abortion, ophthalmologic abnormalities

Question 16

Alcohol

Answer 16

Fetal alcohol syndrome: common cause of birth defects and intellectual disability
- holoprosencephaly

Question 17

Cocaine

Answer 17

abnormal fetal growth and fetal addiction, placental abruption

Question 18

Smoking (nicotine, CO)

Answer 18

low birth weight
preterm labor
placental problems

Nicotine is a vasoconstrictor