Neurotransmitter changes seen with disease FA 507 Flashcards
1
Q
Alzheimers
A
Decrease ACh
Increase glutamate
2
Q
Anxiety
A
Increase NE
Decreased GABA and 5-HT
3
Q
Depression
A
Decreased NE
Decreased Dopamine and 5-HT
4
Q
Huntington Disease
A
Increased Dopamine
Decreased ACh, GABA
5
Q
Parkinson disease
A
Increased ACh
Decreased Dopamine
6
Q
Schizophrenia
A
Increased dopamine
7
Q
Location of synthesis of NE?
A
Locus ceruleus (pons), reitcular formation, solitary tract
8
Q
Location of Dopamine synthesis?
A
Ventral tegmentum and substansia nigra pars compacta (midbrain)
9
Q
Location of 5-HT synthesis?
A
Raphe nuclei (pons, medulla, midbrain)
10
Q
Location of ACh synthesis?
A
Basal nucleus of Meyner
- degradation of this area in Alzheimer’s
11
Q
Location of GABA synthesis
A
Nucleus accumbens (recall this is in the the reward center, pleasures, addition and fear.
