Apolipoproteins or lipoproteins Flashcards
Mediates remnant uptake
Apo E
Activates LCAT
Apo A-1
Lipoprotein lipase cofactor (activation)
Apo-C-2 (Apo C II)
Mediates chylomicron secretion and assembly
-Secretion from enterocyte to lymphatics
Apo-B 48
Binds LDL receptor, LDL particle uptake by hepatocytles
This is needed for LDL to leave liver
Apo- B 100
Secreted by intestinal epithelial cells and delivers dietary TGs to peripheral tissue
Chylomicrons (90%) TGs
Delivers hepatic TGs to peripheral tissue
Secreted by liver
VLDL
Formed in the degradation of VLDL
Delivers TGs and cholesterol to liver
IDL
Delivers hepatic cholesterol to peripheral tissues.
Formed by hepatic lipase (modification of IDL in peripheral tissues)
LDL
This molecule is taken up by receptor mediated endocytosis ( clathrin)
LDL
Which molecule mediates reverse cholesterol transport from periphery to liver?
HDL
Which molecule acts as a repository for apolipoproteins C and E?
HDL
Which molecule increase with alcohol
HDL
High Chylomicrons, TG, and cholesterol seen in blood.
Pancreatitis, hepatosplenomeglly and eruptive/puritic xanthoma
Creamy layer in supernatant
NO increase for atherosclerosis
Familial (AR) hyper-chylomicronemia ( type I)
Caused by lipoprotein lipase deficiency or altered apolipoprotein C 2
High LDL and Cholesterol seen in blood.
Causes accelerated atherosclerosis
Tendon xanthomas
Corneal arcus
MI before age 20
Familial hypercholesterolemia (Type 2a)
Autosomal Dominant
Absent or defective LDL receptors
KEY: MI before age 20
