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USMLE > Antibodies and their diseases > Flashcards

Antibodies and their diseases Flashcards

1
Q

Anti- Smith antibodies

A

Antibodies to spliceosomal snRNPs

  • highly specific for SLE
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2
Q

Anti- ds DNA antibodies

A

SLE

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3
Q

Anti- UR1 RNP antibodies

A

associated with mixed connective tissue disease (MCTD)

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4
Q

Anti- DNase B Titers

A

Acute post streptococcal glomerulonephritis

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5
Q

Anti-ACh receptor

A

Myasthenia gravis

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6
Q

Anti-basement membrane

A

Goodpasture syndrome

against alpha3 chain of collagen type IV

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7
Q

Anticardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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8
Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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9
Q

Anti-desmosomes (anti-desmoglein)

A

Pemphigus vulgaris

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10
Q

Anti-glutamic acid decarboxylase (GAD-65)

A

Type 1 diabetes mellitus

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11
Q

Antihemidesmosome

A

Bullous pemphigoid

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12
Q

Anti-histone

A

Drug-induced lupus

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13
Q

Anti-Jo-1
Anti- SRP
Anti-Mi-2

A

Polymyositis, dermatomyositis

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14
Q

Antimicrosomal, anti-thyroglobulin

A

Hashimoto thyroiditis

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15
Q

Anti mitochondrial

A

primary biliary cirrhosis

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16
Q

Antinuclear antibodies

17
Q

Antiparietal cell

A

Pernicious anemia

18
Q

Anti-Scl-70 (anti-DNA topoisomerase I)

A

Diffuse scleroderma

19
Q

Anti-smooth muscle

A

Autoimmune hepatitis

20
Q

Anti-SSA, Anti-SSB (rho, la)

A

Sjogren syndrome

21
Q

Anti-TSH receptor

A

Grave’s disease

22
Q

IgA anti-endomysial transglutaminase, IgA anti-tissue tranglutaminase

A

Celiac disease

23
Q

MPO-ANA (P-ANCA)

A
  • Microscopic polyangiitis
  • Eosinophilic granulomatosis with polyangiitis
    (aka Churg-Strauss syndrome)
24
Q

PR3-ANCA or c-ANCA

A

Granulomatosis with polyangittis (Wegner)

25
Q

Rheumatoid factor

IgM with IgG Fc region

A

Rheumatoid arthritis

26
Q

anti-CCP

A

Rheumatoid arthritis

-more specific

USMLE (43 decks)

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