Antidotes Flashcards
drugs that can be used to reverse neuromuscular blockade
Cholinesterase inhibitors
- Neostigmine
Drugs that can reverse Digoxin/ cardiac glycosides intoxication?
Digoxin immune FAB
Opioid overdose (Morphine, heroine, methadone)
Naloxone, Naltrexon
Benzodiazepine overdose?
Flumazenil – fyi: can precipitate seizures
Phencyclidine (PCP) overdose
Benzodiazepines, rapid-acting antipsychotic (Haloperidol)
TCA overdose
NaHCO3 (Sodium Bicarb) because TCA are weak acid
Iron
deferoxamine
Lead
EDTA, succimer, or dimercaprol
Cyanide
nitrites, hydroxocobalamin, thiosulfate
methhemoglobin
Methylene blue, Vitamin C
Carbon monoxide
100% O2 and hyperbaric Acid
methanol or ethylene glycol
Fomepizole – inhibits alcohol dehydrogenase
Ethanol
Hemodialysis
Benzodiazepine overdose
Flumazenil
Heparin
Protamine Sulfate
Warfin
Vit K, Fresh Frozen Plasma (FFP)
Thromboyltics overdose
Aminocaproic acid
Myelosuppression caused by Methotrexate
Leucovorin
5- Fluorouracil toxicity
Uridine
hemorrhagic cystitis due to Cyclophosphamide
give mesna
used to prevent cardiotoxicity of doxorubicin and daunorubicin
Dexrazoxane
nephrotoxicity of Cisplatin, Carboplatin, or oxaliplatin
amifostine (free radical scavanger)
Acetaminophen
N-acetylcysteine (replenish glutathione)
AChE inhibitors, organophosphates
Atropine > pralidoxime
Amphetamines
NH4Cl (acidify urine) basic
Antimuscarinic, anticholinergic agents
Physostigmine salicylate, control hyperthermia
Beta blockers
Glucagon
Carbon monoxide
100% oxygen
Copper, arsenic, gold
Penicillamine
Cyanide
Nitrate + Thiosulfate
hydroxocobalamin
Digitalis (digoxin)
Anti-dig Fab fragments
Mercury, arsenic, gold
Dimercaprol (BAL)
Succimer
Salicylates
NaHCO3- (alkalizes urine)
Dialysis
tPA, streptokinase, urokinase
Aminocaproic acid
Methamphetamine overdose
ammonium chloride – helps clear the drug
