TCR Flashcards
Which of the following is NOT True about TCR?
a. All TCRs on a particular T cell have identical idiotypes.
b. CDR3 of TCR has the most sequence variability from molecule to molecule.
c. TCR has binding sites for both antigen and self MHC.
d. TCR is a disulfide-bonded heterodimer.
e. The ab or gd isotype of TCR determines the biological function of its secreted form.
e. The ab or gd isotype of TCR determines the biological function of its secreted form.
The antigen-binding region of TCR is formed by the folding of
a. Va and Vb chains.
b. Va, Vb, and CD3 chains.
c. Va and Vb2-microglobulin chains.
d. Vg and Va chains.
e. VL and VH chains.
a. Va and Vb chains.
Which of the following properties are NOT shared by TCR and BCR?
a. Antigen-binding avidity is increased by the presence of two antigen binding regions on each receptor.
b. Antigen-binding diversity is generated through gene rearrangement.
c. Folding of protein domains is maintained by intrachain disulfide bonds.
d. Membrane expression and lymphocyte activation by antigen require receptors to be associated with signal transduction molecules.
e. Receptor antigen-binding sites are formed from two polypeptide chains.
a. Antigen-binding avidity is increased by the presence of two antigen binding regions on each receptor.
TCR most closely resembles
a. Class I MHC.
b. Class II MHC.
c. Fab region of immunoglobulin.
d. Fc region of immunoglobulin.
e. light chain of immunoglobulin.
c. Fab region of immunoglobulin.
Rearrangement of both TCR and BCR gene segments does NOT
a. generate diversity of antigen binding by recombination of a large pool of germline V, D, and J segments.
b. lead to CDR3 being the most hypervariable region in the receptor chains.
c. require RAG-1, RAG-2, and TdT expression.
d. result in allelic exclusion of membrane receptors.
e. result in isotype switching after antigen stimulation of the mature lymphocytes.
e. result in isotype switching after antigen stimulation of the mature lymphocytes.
The amount of diversity in TCR generated within one individual by somatic recombination
a. is higher than BCR diversity.
b. is about the same as for BCR diversity.
c. is lower than BCR diversity.
d. is lower than Class I MHC diversity.
e. is lower than Class II MHC diversity.
a. is higher than BCR diversity.
T cells use all of the following for generating antigen-recognition diversity on the TCR, except
a. combinatorial association of chains.
b. combinatorial association of segments.
c. large germline pool of gene sequences.
d. N region addition of nucleotides.
e. somatic hypermutation.
e. somatic hypermutation.
CD8 is a co-receptor on T cells that binds
a. CD3.
b. endogenous antigen peptide.
c. the constant region of Class I MHC.
d. the constant region of TCR.
e. the variable region of Class I MHC.
c. the constant region of Class I MHC.
All of the following are true for antigen receptors on both B cells and T cells EXCEPT
a. associated with signal transduction molecules in the membrane.
b. generated by somatic recombination during lymphocyte development.
c. members of the Ig gene superfamily.
d. MHC-restricted in their ability to bind antigen.
e. specific for a single antigen epitope.
d. MHC-restricted in their ability to bind antigen.
Which of the following statements is FALSE?
a. TCR is allelically excluded on individual T cells.
b. CD4 and CD8 co-receptors are also signal transducing molecules for T cell activation.
c. The arrangement of a chain gene segments most closely resembles that of k chain.
d. The gene segments for the d chain are interspersed with those for the g chain.
e. The T cells that are most likely to react against allogeneic kidney cells are CD8+ cytotoxic T cells.
d. The gene segments for the d chain are interspersed with those for the g chain.
