Antigen Flashcards
The ability of an antigen to induce an immune response does NOT depend on the antigen’s
a. ability to enter the thyroid.
b. degree of aggregation.
c. dose.
d. size.
e. usual presence in the body.
a. ability to enter the thyroid.
Alum is an effective adjuvant because it
a. disaggregates the antigen.
b. is immunogenic for stem cells
c. is immunogenic for T cells.
d. slows the release of antigen.
e. transports antigen into the cytoplasm of antigen-presenting cells.
d. slows the release of antigen.
Antibody cross-reactivity is demonstrated by antibody binding to
a. a cell surface marker.
b. a hapten.
c. a hapten-carrier complex.
d. an antigen that is structurally similar to the immunogen
e. the immunogen.
d. an antigen that is structurally similar to the immunogen
The antibiotic penicillin is a small molecule that does not induce antibody formation. However, penicillin binds to serum proteins and forms a complex that in some people induces antibody formation resulting in an allergic reaction. Penicillin is therefore
a. an antigen.
b. a hapten.
c. an immunogen.
d. both an antigen and a hapten.
e. both an antigen and an immunogen.
d. both an antigen and a hapten.
Antigen entering the body in a subcutaneous injection activates its specific lymphocytes in the
a. blood circulation.
b. draining lymph nodes.
c. MALT.
d. skin.
e. spleen.
b. draining lymph nodes.
To detect a humoral immune response to influenza virus, you would measure
a. cytotoxicity of virus-infected cells in the lung.
b. cytotoxicity of virus-infected cells in tissue culture.
c. dividing T cells in the draining lymph nodes.
d. plasma cytokine levels.
e. serum antibody titer.
e. serum antibody titer.
During the lag period between antigen contact and detection of adaptive immunity,
a. antigen is hidden from the immune system in macrophages.
b. cellular immunity can be detected but antibodies cannot.
c. innate immune effectors are eliminating antigen.
d. innate immunity blocks the activation of adaptive immune effector cells.
e. new B and T cells with the appropriate antigen specificity must be produced in the bone marrow.
c. innate immune effectors are eliminating antigen.
To elicit the best antibodies to mouse MHC I, you should inject it into
a. a goat.
b. a mouse of the same genetic background (strain).
c. a mouse of a different strain.
d. a rat.
e. the mouse you isolated it from.
a. a goat.
For specific antigen recognition by T cells,
a. antigen is bound by a T cell membrane antibody.
b. denaturation of antigen does not reduce epitope recognition.
c. MHC molecules are not required.
d. soluble antigen is bound directly without processing.
e. antigen exposure during T cell maturation is required.
b. denaturation of antigen does not reduce epitope recognition.
The immune response to a booster vaccine is called a(n)
a. cellular response.
b. humoral response.
c. innate response.
d. primary response.
e. secondary response.
e. secondary response.
Immunogenicity
a. depends on the ability of the native antigen to be presented by MHC.
b. is usually a property of “self” antigens such as eye tissue.
c. is not a property of antibodies.
d. is not a property of haptens.
e. only applies to antigens that are composed of proteins.
d. is not a property of haptens.
??????a. depends on the ability of the native antigen to be presented by MHC.
Lymphocytes are activated by antigen in the
a. blood stream.
b. bone marrow.
c. liver.
d. lymph nodes.
e. skin.
d. lymph nodes.
A molecule that can be covalently linked to a non-immunogenic antigen to make it an immunogen is called a(n)
a. adjuvant.
b. carrier.
c. hapten.
d. mitogen.
e. superantigen.
b. carrier.
A polyclonal antibody response
a. is not antigen-specific.
b. is produced only in response to polymeric antigens.
c. is produced by several B cells recognizing different epitopes on the same antigen.
d. occurs during the lag phase of the immune response.
e. violates clonal selection.
c. is produced by several B cells recognizing different epitopes on the same antigen.
Very low doses of antigen may induce
a. a secondary response.
b. hypersensitivity.
c. immunological ignorance.
d. low zone tolerance.
e. low zone immunity.
d. low zone tolerance.
