Immune Deficiencies Flashcards
Combined cellular and humoral immune deficiencies result from lack of all of the following EXCEPT
a. a thymus.
b. Class II MHC.
c. HIV infection of CD4 T cells.
d. RAG-1 or RAG-2 products.
e. TAP.
e. TAP.
If Class II MHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following EXCEPT reduced
a. alternative complement activation.
b. CD8 T cell-mediated cytotoxicity.
c. macrophage activation to vesicular pathogens.
d. IgG synthesis.
e. All of the above would be involved.
a. alternative complement activation.
Infants are most susceptible to bacterial infection due to low circulating levels of IgG
a. in utero (before birth).
b. at 0-3 months of age.
c. at 3-12 months of age.
d. at 12-24 months of age.
e. after the age of 2 years.
c. at 3-12 months of age.
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with
a. CTL killing of viruses.
b. dendritic cell activation to become a mature APC.
c. infected cell processing of virus peptides.
d. macrophage intracellular killing of bacteria.
e. M cell uptake of mucosal antigens.
d. macrophage intracellular killing of bacteria.
Bare lymphocyte syndrome due to lack of Class I MHC expression would be expected to result in an inability to
a. activate Th1 cells to promote macrophage killing of vesicular pathogens.
b. educate any T cells in the thymus.
c. make an inflammatory response to bacterial LPS.
d. produce any CD8 T cells.
e. process endogenous antigen for presentation.
d. produce any CD8 T cells.
X-linked Hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be
a. activation of B cells by T-independent antigens.
b. failure of B cells to provide co-stimulation for Th2 activation.
c. failure of dendritic cells to provide co-stimulation for Th2 activation.
d. failure of Th2 cells to provide co-stimulation for B cell isotype switching.
e. failure of Th2 cells to provide co-stimulation for B cell proliferation.
d. failure of Th2 cells to provide co-stimulation for B cell isotype switching.
DiGeorge’s syndrome is characterized by the lack of a thymus. The mouse model closest to this human disease would be a
a. knock-out mouse for RAG-1 and RAG-2.
b. knock-out mouse for a thymus.
c. nude mouse.
d. recombinant mouse for CD3.
e. SCID mouse.
c. nude mouse.
A selective IgA deficiency would be expected to result in problems with
a. bacterial infections.
b. infections following dental work due to bacteria entering the bloodstream.
c. mucosal pathogens.
d. pathogens which can survive inside macrophages.
e. viral infections.
c. mucosal pathogens.
Bone marrow given to an infant with SCID must
a. be irradiated to eliminate GVHD.
b. contain hematopoietic stem cells that have been transduced with corrected copies of defective genes.
c. contain mature T cells that can begin making immune responses immediately.
d. come from a donor that shares some MHC alleles with the recipient.
e. come from one of the child’s parents.
d. come from a donor that shares some MHC alleles with the recipient.
Difficulties with somatic gene therapy arise from all of the following EXCEPT
a. GVHD caused by mature T cells in the transplanted cells.
b. inserting a gene so that it will function properly.
c. limited life span of more mature hematopoietic cells.
d. obtaining enough stem cells.
e. transducing genetic material into stem cells.
a. GVHD caused by mature T cells in the transplanted cells.
