Other PQs

Question 1

A cytokine do all of the following EXCEPT
a. Bind to receptor which do not share cytokine binding subunits
b. Bind to its specific receptor on the same cell that produced it
c. Bind to receptor antagonists produced by pathogenic viruses
d. Compete with other cytokines whose receptor share signal transducing subunits

Answer 1

b. Bind to its specific receptor on the same cell that produced it

Question 2

In classical pathway are activated complement components in the order
a.C1, CC4, 2, C3, C5, C6,C7, C8, C9
b.C3, B, C5, C6, C7, C8, C9
c. MBP, MASP, C4, C2, C3, C5, C6, C7, C8, C9
d. C1, C2, C3, C4, C5, C6, C7, C8, C9

Answer 2

d. C1, C2, C3, C4, C5, C6, C7, C8, C9

Question 3

Effector function of complement include all of the following EXCEPT
a.Attracted phagocytes to the site of infection
b. Increased blood vessel permeability to plasma protein
c.Lysine bacterial cells
d.Presenting antigen to B cells

Answer 3

d.Presenting antigen to B cells

Question 4

The immunoglobulin isotope is determined by the
a.Antigen specificity
b.H chain constant region
c.L chain constant region
d.Number of antigen binding site

Answer 4

b.H chain constant region

Question 5

For IgG immunoglobulin isotype select the description(s) listed below that describes this isotope
a.Secreted form is pentamere
b. Binds to Fc receptors on mast cells
c.Multimers forms have a J chain
d.The most abundant isotype in serum
e.Major antibody in secretions such as saliva, tears and breast milk
f.Present on the surface of immature B cells
g.The first serum antibody made in a primary immune response
h. Plays an important role in immediate hypersensitivity
i.Plays primary role in protecting against pathogens that invade through the gut or respiratory mucosa i.
j. Multimedia forms may contain a secretory component
k.Least abundant isotype in serum

Answer 5

b. Binds to Fc receptors on mast cells
d.The most abundant isotype in serum
h. Plays an important role in immediate hypersensitivity

Question 6

Bone marrow storm all cells
a.Are present only in the center of the marrow
b.Present foreign antigen to B cell to stimulate somatic Hypermutation
c.Present self antigen on self MHC to B cell for negative selection
d.Secrete cytokines such as IL7 that signal developing B cells to divide and differentiate

Answer 6

d.Secrete cytokines such as IL7 that signal developing B cells to divide and differentiate

Question 7

The B cells which the longest life span are the
a.Immature B cells
b.Mature naïve B cells
c. Memory cells
d.Plasma cells

Answer 7

c. Memory cells

Question 8

Dendritic cells are the best APC for
a. CTL
b. Helper T cell
c. Naïve T cell
d. NK cell

Answer 8

c. Naïve T cell

Question 9

The function of M cells is to
a.Induce a food allergy
b. Kill infected enterocytes
c. Migrate to the Peyer’s patches and present antigen to T cells
d. Phagocytose or endocytose antigen

Answer 9

d. Phagocytose or endocytose antigen

Question 10

Which situation below describes an example of innate immunity
a. Antibody production by plasma cell
b. Cemplement activation by component of bacterial surface
c. Recognition and killing of cancer cells by NK cell d. B and C

Answer 10

b. Cemplement activation by component of bacterial surface

Question 11

A secondary immune response is
a.Faster than a primary response
b. Larger than a primary response
c. Longar lasting than a primary response
d.All are true

Answer 11

a.Faster than a primary response

Question 12

During a primary immuen response are predominantly secreted
a. IgG
b. IgM
c. IgA
d. IgE

Answer 12

b. IgM

Question 13

Write IgG, IgM, IgA or IgE to the selected statements that describe their isotype. Each description may be used once, more than once or not at all.

a. Secreted form is a pentamer
b. Multimeric forms have a J chain
c. The most abundant isotype in serum
d. Major antibody in secretions such as saliva, tears and breast milk
e. The first serum antibody made in primary immune response
f. Plays an important role in immediate hypersensitivity
g; Plays primary role in protecting against pathogens that invade through the gut or resporatory mucosa.

Answer 13

a.IgM b. IgA c. IgG d. IgA e. IgM f. IgE g. IgA

Question 14

Macrophages are
a. Leukocytes
b. Phagocytes
c. APCs
d. All of the above

Answer 14

d. All of the above

Question 15

Respiratory burst is
a.An increased oxygen consumption by professional phagocytes
b.Process by which professional phagocytes can generate reactive oxygen intermediates necessary for the killing of phagocyttized microorganisms.
c.Process by which professional phagocytes can participate on damaging of body’s own cells and tissues in immunopathological reactions
d.All of the above

Answer 15

d.All of the above

Question 16

Complement is activated by the presence of
a. Cytokines
b. Antigen
c. Allergens
d. Antibodies

Answer 16

d. Antibodies

Question 17

T lymphocytes are characteried by the presence of ……….. Antigen
a. CD3
b. CD4
c. CD8
d. CD19

Question 18

Cells which have MHC class II are ____, which present exogenous antigens to ____ T helper cells.

Answer 18

antigen-presenting cells (APCs)
CD4+

Question 19

Negative selection of T lymphocytes ensures that:
a. The T cell that recognize self MHC molecule survive.
b. The T cell that recognize self MHC molecule are killed
c. The T cell that recognize self antigen survive
d. The T cell that recognize self antigen are killed

Answer 19

d. The T cell that recognize self antigen are killed

Question 20

For specific antigen recognition by T cells :
a. Antigen is bound by a T cell membrane antibody
b. Processing of antigen in APC is required
c. MHC molecules are not required
d. Soluble antigen is bound directly without processing

Answer 20

b. Processing of antigen in APC is required

Question 21

Th2 cells secrete cytokines which:
a. Inhibit macrophages secretion of inflammatory cytokines
b. Stimulate B cells to secrete neutrlizing antibodies
c. Inhibit proliferation of Th1 cells
d. All of the above

Answer 21

d. All of the above

Question 22

Cytotoxic T lymphobytes use perforin to
a. Activate the classical complement cascate to lyse the target
b. Allow granzymes to enter the target cell and initate apoptosis
c. Promote target cell lysis by macrophages
d. Substitute for C9 in the alternative complement pathway.

Answer 22

b. Allow granzymes to enter the target cell and initate apoptosis

Question 23

The role of NK cells involves all of the following EXCEPT
a. Killing of cancer cell
b. Killing of virus infected cell
c. Phagocytosis of extracellular pathogen
d. Production of cytokines

Answer 23

c. Phagocytosis of extracellular pathogen

Question 24

Effects of the toxin can be interrupted by :
a. Antibody binding to the toxin
b. Antibody binding to bacteria that produces this toxin
c. B cell binding to bacteria that produces this toxin
d. Cytotoxic T cell binding and lysis of bacteria which produce this toxin

Answer 24

a. Antibody binding to the toxin

Question 25

Match each type of cells with the most appropriate description of their function.
Each description may be used once, or not at all.
a. M cells - antigen collection on mucosal surface
b. Macrophages - Phagocytosis and antigen presentation
c. Dendritic cells - Antigen presentation
d. Eosinophil granulocytes - killing of worm parasites
e. Neutrophil granulocytes - phagocytosis
f. Basophil granulocytes - stimulation of inflammation and allergic reaction

Question 26

Primary lymphoid organs:
a. are designed to maximise contact between antigen and lymphocytes.
b. provide the microenvironment for maturation of T and B cells.
c. filter blood and trap blood-borne antigens.
d. are efficient in exposing T cells to foreign antigen

Answer 26

b. provide the microenvironment for maturation of T and B cells.

Question 27

CD characteristic of cytotoxic T cells is….

Answer 27

CD4+CD8+ (Th Tc)