TCA cycle

Question 1

how does pyruvate get into the mitochondria

Answer 1

through porins

Question 2

pyruvate is transported into the inner membrane by

Answer 2

pyruvate transporter

Question 3

pyruvate to acetyl CoA

Answer 3

pyruvate dehydrogenase complex

Question 4

pyruvate loses and gains what to become acetyl coa

Answer 4

losses: H+ and CO2
gains: CoA-s-

Question 5

prosthetic group, TPP required for what

Answer 5

pyruvate dehydrogenase

Question 6

prosthetic group, lipoate is required for what

Answer 6

transfer of acetyl group of CoA

Question 7

FAD is required to

Answer 7

regenerate Lipoate which then gives those H+ to NAD+

Question 8

thiamine (vitamin b1) lack causes

Answer 8

thiamine deficiency, stops pyruvate metabolism

Question 9

why do we need a enzyme complex

Answer 9

the product of one is passed to the next stright away without it reacting to form something else elsewhere.
also speed is needed

Question 10

pyruvate can be turned to oxaloacetate how?

Answer 10

carboxylation
loss of CO2
gain Pi from ATP

Question 11

tca intermediates cannot do what?

Answer 11

cannot be directly used to form energy

needs to be converted to acetyl coa first

Question 12

OAA is converted to phosphoenolpyruvate

Answer 12

PEP carboxykinase
so loss of CO2
gain of a Pi by GTP

Question 13

as Acetyl CoA levels rise, pyruvate is converted more into OAA this is because of a

Answer 13

negative feedback loop

Question 14

pyruvate dehydrogenase is tightly controlled by

Answer 14

phosphorylation reaction to activate and deactivate it