Gluconeogenesis Flashcards
in the absence of——, most of the body use——— ————–for energy
insulin
Fatty acids
brain and RBC only use
Glucose
pyruvate to PEP (1st step)
Atp-ADP
HCO3- to HOCO2
use biotin prosthetic group
pyruvate carboxylase
forms OAA
pyruvate to PEP (2nd step)
OAA + GTP —- PEP + GDP + CO2
where does it happen
PEP carboxykinase
cytoplasm
irreversible reaction 2
fructose 1,6 bisphosphate + H2O —- F-6-p + Pi
type of reaction?
where?
Fructose 1,6 bisphosphotase
hydrolysis
cytoplasm
irreversible reaction 3
G-6-P + H2O ——- Glucose + Pi
Glucose 6 phosphotase
what cant G-6-P do?
cant leave the bilayer
we dont have Glucose 6 phosphotase in what part of the body?
muscles
problems with gluconeogenesis
no stores of pyruvate to maintain gluconeogenesis
solution to problem
lactate cori cycle
lactate cori cycle
glucose – pyruvate – latcate
lactate —–(LDH)—— pyruvate—–glucose
glucogenic amino acids
what is used to make glucose in the muscles?
alanine
muscle catabolism releases
alanine into blood the converted into pyruvate
glycerol can be converted into
dihydroxyacetone phosphate
dihydroxyacetone phosphate can be attached to
glyceraldehyde 3 phosphate to produce F-1,6-bisp