TBL Baby! Flashcards
What is the “line of no effect” in a forest plot for a meta analysis?
If the confidence interval includes “1” / crosses the line there is no significant difference
Case-control study
Compares group with and without disease to identify risk factors
Cross-sectional study
assess frequency of disease at a particular point in time
Cohort study
compares group with exposure to group without to assess what will happen
Randomize Controlled Trial
compare therapeutic benefits
Meta-Analysis
Pools data from several studies
Confounding
failure to account for this variable may lead to a spurious relationship.
What is at the top of the hierarchy of evidence? The bottom?
Top = meta-analysis - because it compares evidence across multiple studies
Bottom= animal research lab studies
What is the benefit of a cross-over design?
Each person serves as his/her own control so there is reduced influence of confouding covariates
3 things that cause dumping syndrome?
- sugary meal
- vagotomy
- gastric bypass surgery
Mechanism for dumping syndrome
- Rapid emptying of stomach into duodenum
- water follows
- hypovolemic
- low BP
- tachycardic
Rapid dumping also gives you insulin surge - so become hypoglycemia
Possible therapy for dumping syndrome?
Pasireotide = somatostatin analog
- inhibits insulin release
- causes vasocontriction
- inhibits G cell gastrin release
Did parsierotide have an effect?
No significant difference
What is the best therapeutic option for dumping syndrome?
Diet change
Small amounts only
Low if fats
Evaluate the radioablation in the treatment of Barrett’s esophagus
ablation showed statistically significant reduction in the progression of low grade dysplasia to Barrett’s esophagus
