TB drugs

Question 1

neurotixicity caused by isoniazid can be prevented by

Answer 1

Vitamin B6

Question 2

Common side effects of isoniazid

Answer 2

INH

injures neurons and hepatoxytes

Question 3

CYP450 inducer

Answer 3

rifampicin

Question 4

Rifampin derivative that is not absorbed in the GIT so is used for the prevention of hepatic encephalopathy, for travellers diarrhea

Answer 4

Rifaximin

Question 5

resistance is due to changes of drug sensitivity of the polymerase enzyme

Answer 5

rifampicin

Question 6

resistance is due to deletion of KatG gene which codes for catalase-peroxidase enzyme involved in its bioactivation

Answer 6

INH

Question 7

SimD to rifampicin, preferred drug TB with AIDS px

Answer 7

rifabutin

Question 8

RNA polymerase inhibito
Red-orange body fluids
Rapid development of resistance
Revs up CP450 (inducer)

Answer 8

Rifampicin

Question 9

Hepatotoxicity
Non-gouty polyarthralgia
Asymptomatic hyperuricemia
Myalgia
GIT irritation
Rash
Porphyria
Photosensitivity

Answer 9

Pyrazinamide

Question 10

“sterilizing agent” used during the first 2 months of therapy

Answer 10

Pyrazinamide

Question 11

Most hepatotoxic Anti-TB drug

Answer 11

Pyrazinamide

Question 12

Resistance is due to mutation in pncA gene and increased efflux systems

Answer 12

Pyrazinamide

Question 13

Most active drug against M. leprae

Answer 13

dapsone

Question 14

Prophylaxis for atypical mycobacterial infection in patients with CD4 count lest than 50/L

Answer 14

clarithromycin or azithromycin with or without rifabutin