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topnotch pharma boxes mgcmd > Drugs for Dyslipidemia > Flashcards

Drugs for Dyslipidemia Flashcards

1
Q

2 drugs that lower TAG and VLDL, increase HDL

A

niacin, fibrates

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2
Q

Statins

A

lower LDL

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3
Q

Resins

A

lower LDL

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4
Q

Ezetimibe

A

lower LDL

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5
Q

Niacin

A

lower LDL

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6
Q

CYP450 inhibitors that increase effects of statins

A 
Inhibitors Stop Cyber Kids from Eating GRApefruit QV
isoniazid
sulfonamides
cimetidine
ketoconazole
erythromycin
grapefruit juice
ritonavir
amiodarone
quinidine
valproic acid
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7
Q

3 drugs not to be given in px with high TAG

A

Cholestyramine
colestipol
colesevelan
(Bile acid binding resins)

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8
Q

drugs that cause flushing (4)

A 
VANC
Vancomycin
adenosine
niacin
CCB
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9
Q

MOA of fibrates

A

upregulates lipoprotein lipase

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10
Q

Clinical use

Statin + Niacin

A

familial hypercholesterolemia

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11
Q

Clinical use

statin + ezetimibe

A

familial hypercholesterolemia

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12
Q

Clinical use

Niacin + resin

A

familial combined hypercholesterolemia

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13
Q

Clinical use

Statin + fibrate

A

familial combined hypercholesterolemia

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14
Q

Disadvantage

fibrate + resin

A

cholelithiasis

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15
Q

Disadvantage

statin + resin

A

impaired statin absorption

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16
Q

Disadvantage

statin + fibrate

A

increased myopathy and rhabdomyolysis

17
Q

Drug class for high LDL

A

statin

then ezetimibe

18
Q

Drug class for high VLDL

A

statin

then fibrate

19
Q

Drug class for high TAG

A

fibrates

then niacin

20
Q

Drug class for low HDL

A

Niacin

21
Q

Drug class for high LDL and VLDL

A

Statin then ezetimibe or niacin

22
Q

Drug class for high LDL, VLDL and low HDL

A

statin, niacin, ezetimibe

23
Q

Type I

A

Primary hyperchylomicronemia

24
Q

type IIA

A

Familial hypercholesterolemia

25
Q

type IIB

A

familial comBined hypercholesterolemia

26
Q

type III

A

familial dysbetalipoproteinemia

27
Q

type IV

A

familial hyperTAG

28
Q

type V

A

familial combined hyperTAG

29
Q

deficiency in LPL or ApoC II

A

Type I Primary hyperchylomicronemia

30
Q

Increased chylomicrons

inc TAG

A

Type I Primary hyperchylomicronemia

31
Q

increased LDL

normal VLDL

A

type IIa familial hypercholesterolemia

32
Q

defect in LDL receptors

A

type IIa familial hypercholesterolemia

33
Q

increased LDL

increased VLDL

A

type IIb familial combined hypercholesterolemia

34
Q

overproduction of VLDL

A

type IIb familial combined hypercholesterolemia

35
Q

deficiency in ApoE

A

type III familial dysbEtalipoproteinemia

36
Q

increased VLDL remnants

increased chylomicrons

A

type III familial dysbEtalipoproteinemia

37
Q

decreased clearance of VLDL

A

Type IV familial TAG

type V familial combined TAG

38
Q

inc TAG
increased VLDL
decreased/normal LDL

A

Type IV familial TAG

39
Q

Increased TAG
increased chylomicrons
increase VLDL
dec/normal LDL

A

type V familial combined hyperTAG

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