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topnotch pharma boxes mgcmd > Anti HTN > Flashcards

Anti HTN Flashcards

1
Q

Drug-induced lupus (4)

A 
It's HIPP to have lupus
Hydralazine
Isoniazid
Procainamide
Penicillamine
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2
Q

why do patients taking ACEi/ARBs develop hyperkalemia

A

reduced aldosterone levels–> potassium retention

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3
Q

Why give ACEi in px with DM nephropathy

A

Renoprotective (decreases albumin excretion and slows progression of micro- to macroalbuminuria

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4
Q

Cause of headache in px taking nitrates

A

meningeal blood vessel dilatation

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5
Q

Why is Ca-dependent neurotransmission not affected by CCB?

A

CCBs affect L-type Ca channels

other fxns use N-, P- and R- type

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6
Q

Drugs that cause gingival hyperplasia (4)

A 
NapaCa-Pangit ng gingiVa mo
Nifedipine
Cyclosporine
Phenytoin
Verapamil
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7
Q

Complex in ETC affected by cyanide

A

Complex IV

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8
Q

Antidote for cyanide poisoning

A

inhaled amyl nitrite + IV sodium nitrite + IV sodium thiosulfate

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9
Q

Nitrates alone

Heart rate

A

Reflex increase

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10
Q

Nitrates alone

arterial pressure

A

decrease

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11
Q

Nitrates alone

end-diastolic pressure

A

DECREASE

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12
Q

Nitrates alone

contractility

A

reflex increase

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13
Q

Nitrates alone

ejection time

A

reflex decrease

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14
Q

Nitrates alone

Net myocardial oxygen requirement

A

decrease

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15
Q

BB or CCB alone

heart rate

A

decrease

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16
Q

BB or CCB alone

arterial pressure

A

decrease

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17
Q

BB or CCB alone

end-diastolic pressure

A

increase

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18
Q

BB or CCB alone

contractility

A

decrease

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19
Q

BB or CCB alone

ejection time

A

decrease

20
Q

BB or CCB alone

net myocardial oxygen requirement

A

decrease

21
Q

combined BB or CCB and nitrates

heart rate

A

decrease

22
Q

combined BB or CCB and nitrates

arterial pressure

A

decrease

23
Q

combined BB or CCB and nitrates

end-diastolic pressure

A

decrease

24
Q

combined BB or CCB and nitrates

contractility

A

no effect or decrease

25
Q

combined BB or CCB and nitrates

ejection time

A

no effect

26
Q

combined BB or CCB and nitrates

net myocardial oxygen component

A

decrease

27
Q

orthopnea, PND, pulmonary congestion

A

left sided heart failure

28
Q

hepatomegaly, edema, engorded neck veins

A

right sided heart failure

29
Q

Drugs with narrow therapeutic index

A 
WALA na Cyang PaPa, VasTeD na
warfarin
aminoglycosides
lithium
amphotericin B
carbamazepine
phenobarbital
phenytoin
vancomycin
theophylline
digoxin
30
Q

3 drug classes that increase survival in CHF

A

ACE inh
Beta blockers
Aldosterone antagonists

ito yung iaadd mo sa loop diuretics pag CHRONIC HF

31
Q

Effects of Class I antiarrhythmics to AP duration

A

Class IA prolong
Class IB shorten
Class IC no change

32
Q

Class IA antiarrhytmics

A

Procainamide
disopyramide
quinidine

33
Q

tx for Class IA antiarhythmic toxicity

A

Sodium lactate to reverse arrythmia

pressor sympathomimetics

34
Q

Class IB antiarrhythmics

A

I Buy Mexican Tacos from Lily

IB: mexiletine, tocainide, lidocaine

35
Q

drugs that cause agranulocytosis

A 
CCCAPPIT Me
clozapine
cotrimoxazole
colchicine
aminopyrine
phenylbutazone
PTU
Indomethacin
Tocainide
Methimazole
36
Q

Class IC antiarrhythmics

A

Chicken ay Pagkain For Enrico

IC: Propafenone, Encainide, Flecainide

37
Q

Non-selective beta blockers

A

propanolol, timolol

38
Q

Beta1 selective blockers

A

esmolol, acebulol, betaxolol, atenolol, metoprolol

39
Q

Beta blocker with partial agonistic properties

A

pindolol, acebulol

40
Q

BB lacking local anesthetic effects

A

timolol

41
Q

BB with low lipid solubility

A

atenolol

42
Q

shortest acting BB

A

esmolol

43
Q

longest acting BB

A

nadolol

44
Q

combine a and b blockade

A

carvedilol, labetalol

45
Q

Amiodarone toxicity

A 
pulmonary fibrosis
Paresthesias
Tremors
thyroid dysfunction
Corneal deposits
skin deposits

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