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topnotch pharma boxes mgcmd > Skeletal Muscle Relaxants > Flashcards

Skeletal Muscle Relaxants Flashcards

1
Q

NMB

SHORT ACTING

A

Mivacurium

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2
Q

NMB

long acting

A

Tubocurarine

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3
Q

Spasmolytic
Chronic use
Muscle action

A

Dantrolene

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4
Q

Spasmolytic
Chronic use
CNS action

A

Baclofen
Diazepam
Tizanidine

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5
Q

Spasmolytic

Acute use

A

Cyclobenzamine

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6
Q

Neuromuscular paralysis that results from persistent depolarization of the end plate

A

Depolarizing blockade

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7
Q

Neuromuscular paralysis

Pharmacologic antagonism at the Ach receptor of the end plate

A

Non depo or stabilizing blockade

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8
Q

Drugs metabolized in bile have _____ DOA than those eliminated in kidney

A

Shorter

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9
Q

Metabolized by cholinesterase

A

Mivacurium

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10
Q

Eliminated in bile

A

Vecuronium

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11
Q

Renal elimination

A

Metocurine, pancuronium
Pipecuronium
Tubocurarine

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12
Q

Atracurium undergoes rapid spontaneous breakdown to form _____ that can cause seizures

A

Laudanosine

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13
Q

Relatively contraindicated in MI

A

Tubocurarine

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14
Q

Metabolized by pseudocholinesterase

A

Mivacurium

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15
Q

Muscle relaxation is enhance by aminoglycisides and quinidine

A

Vecuronium

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16
Q

Novel reversal for rocuronium

A

Sugammadex

17
Q

Slight antimuscarinic effects

Useful in px with renal impairment

A

Rocuronium

18
Q

Most rapid onset time

A

Rocuronium

19
Q

Heart block

A

Pancuronium

20
Q

Drugs for lethal injection

A

Thiopental 5g
Pancuronium100 mg
KCl 100meq

21
Q

Early sign of malignant hyperthermia

A

Trismus (contraction of jaw muscles)

22
Q

Centrally acting spasmolytic

Used for muscle spasm due to cerebral palsy, multiple sclerosis, stroke

A

Baclofen

23
Q

Centrally acting spasmolytic
Used for muscle spasm due to stroke, multiple sclerosis, ALS

a2 agonist on SC

A

Tizanidine

24
Q

Direct acting muscle relaxant

A

Dantrolene

25
Q

MOA dantrolene

A

Blocks RyR1 Ca-release channels in the sarcoplasmic reticulum of the skeletal muscle

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