Skeletal Muscle Relaxants Flashcards
NMB
SHORT ACTING
Mivacurium
NMB
long acting
Tubocurarine
Spasmolytic
Chronic use
Muscle action
Dantrolene
Spasmolytic
Chronic use
CNS action
Baclofen
Diazepam
Tizanidine
Spasmolytic
Acute use
Cyclobenzamine
Neuromuscular paralysis that results from persistent depolarization of the end plate
Depolarizing blockade
Neuromuscular paralysis
Pharmacologic antagonism at the Ach receptor of the end plate
Non depo or stabilizing blockade
Drugs metabolized in bile have _____ DOA than those eliminated in kidney
Shorter
Metabolized by cholinesterase
Mivacurium
Eliminated in bile
Vecuronium
Renal elimination
Metocurine, pancuronium
Pipecuronium
Tubocurarine
Atracurium undergoes rapid spontaneous breakdown to form _____ that can cause seizures
Laudanosine
Relatively contraindicated in MI
Tubocurarine
Metabolized by pseudocholinesterase
Mivacurium
Muscle relaxation is enhance by aminoglycisides and quinidine
Vecuronium
Novel reversal for rocuronium
Sugammadex
Slight antimuscarinic effects
Useful in px with renal impairment
Rocuronium
Most rapid onset time
Rocuronium
Heart block
Pancuronium
Drugs for lethal injection
Thiopental 5g
Pancuronium100 mg
KCl 100meq
Early sign of malignant hyperthermia
Trismus (contraction of jaw muscles)
Centrally acting spasmolytic
Used for muscle spasm due to cerebral palsy, multiple sclerosis, stroke
Baclofen
Centrally acting spasmolytic
Used for muscle spasm due to stroke, multiple sclerosis, ALS
a2 agonist on SC
Tizanidine
Direct acting muscle relaxant
Dantrolene
MOA dantrolene
Blocks RyR1 Ca-release channels in the sarcoplasmic reticulum of the skeletal muscle
