Anticoagulants Flashcards
expected acid-base abnormality in salicylate poisoning
respiratory alkalosis with HAGMA
Presentation of salicylate poisoning in adults
Mixed acid-base disorder (respiratory alkalosis with High Anion Gap Metabolic Acidosis)
Presentation of salicylate poisoning in children
Pure acid-base disorder (respiratory alkalosis)
Differentiate inhibitor from uncoupler of oxidative phosphorylation
inhibitor- completely halts ETC
ucoupler - dissipate proton gradient without interrupting ETC
Mainly for prevention and tx of venous thrombosis (pulmonary embolism and DVT)
anticoagulants
lab test
extrinsic pathway
PT
lab test
intrinsic pathway
PTT
heparin vs warfarin
large acidic, polysaccharide
heparin
heparin vs warfarin
small-lipid soluble
warfarin
heparin vs warfarin
parenteral
heparin
heparin vs warfarin
oral
warfarin
heparin vs warfarin
site of action is blood
heparin
heparin vs warfarin
site of action is liver
warfarin
heparin vs warfarin
onset of action is rapid
heparin
heparin vs warfarin
slow onset
warfarin
heparin vs warfarin
activates antithrombin III
heparin
heparin vs warfarin
impairs post-translational modification of factors II, VII, IX, X (vitamin k dependent)
warfarin
heparin vs warfarin
PTT for monitoring
heparin
heparin vs warfarin
PT for monitoring
warfarin
antidote for heparin
protamine
antidote for warfarin
vitamin K, FFP
heparin vs warfarin
used for mostly acute, over days
heparin
heparin vs warfarin
used for chronic, over weeks to months
warfarin
heparin vs warfarin
may give to pregnant patients
hepatin
warfarin is category X
CYP450 inducers that increase clearance of warfarin
Ethel Booba takes Phen-Phen and Refuses to Greasy Carb Shakes Ethanol barbiturates phenytoin rifampicin
griseofulvin
carbamazepine
St johns wort/ smoking
CYP450 inhibitors that decrease effects of warfarin
Inhibitors Stop Cyber Kids from Eating GRApefruit Q isoniazid sulfonamides cimetidine ketoconazole erythromycin
grapefruit
ritonavir
amiodarone
quinidine
