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Topnotch Pharma Boxes mgcMD > Anticoagulants > Flashcards

Anticoagulants Flashcards

1
Q

expected acid-base abnormality in salicylate poisoning

A

respiratory alkalosis with HAGMA

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2
Q

Presentation of salicylate poisoning in adults

A

Mixed acid-base disorder (respiratory alkalosis with High Anion Gap Metabolic Acidosis)

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3
Q

Presentation of salicylate poisoning in children

A

Pure acid-base disorder (respiratory alkalosis)

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4
Q

Differentiate inhibitor from uncoupler of oxidative phosphorylation

A

inhibitor- completely halts ETC

ucoupler - dissipate proton gradient without interrupting ETC

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5
Q

Mainly for prevention and tx of venous thrombosis (pulmonary embolism and DVT)

A

anticoagulants

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6
Q

lab test

extrinsic pathway

A

PT

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7
Q

lab test

intrinsic pathway

A

PTT

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8
Q

heparin vs warfarin

large acidic, polysaccharide

A

heparin

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9
Q

heparin vs warfarin

small-lipid soluble

A

warfarin

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10
Q

heparin vs warfarin

parenteral

A

heparin

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11
Q

heparin vs warfarin

oral

A

warfarin

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12
Q

heparin vs warfarin

site of action is blood

A

heparin

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13
Q

heparin vs warfarin

site of action is liver

A

warfarin

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14
Q

heparin vs warfarin

onset of action is rapid

A

heparin

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15
Q

heparin vs warfarin

slow onset

A

warfarin

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16
Q

heparin vs warfarin

activates antithrombin III

A

heparin

17
Q

heparin vs warfarin

impairs post-translational modification of factors II, VII, IX, X (vitamin k dependent)

A

warfarin

18
Q

heparin vs warfarin

PTT for monitoring

A

heparin

19
Q

heparin vs warfarin

PT for monitoring

A

warfarin

20
Q

antidote for heparin

A

protamine

21
Q

antidote for warfarin

A

vitamin K, FFP

22
Q

heparin vs warfarin

used for mostly acute, over days

A

heparin

23
Q

heparin vs warfarin

used for chronic, over weeks to months

A

warfarin

24
Q

heparin vs warfarin

may give to pregnant patients

A

hepatin

warfarin is category X

25
Q

CYP450 inducers that increase clearance of warfarin

A 
Ethel Booba takes Phen-Phen and Refuses to Greasy Carb Shakes
Ethanol
barbiturates
phenytoin
rifampicin

griseofulvin
carbamazepine
St johns wort/ smoking

26
Q

CYP450 inhibitors that decrease effects of warfarin

A 
Inhibitors Stop Cyber Kids from Eating GRApefruit Q
isoniazid
sulfonamides
cimetidine
ketoconazole
erythromycin

grapefruit
ritonavir
amiodarone
quinidine

Topnotch Pharma Boxes mgcMD (22 decks)

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