Talley and O'Connor Mushkies Flashcards
What are the CAGE questions?
Cut down
Annoyed
Guilty
Eye opener
What are the AUDIT-C questions?
- How often do you have a drink containing alcohol?
- How many drinks containing alcohol do you have on a typical day when you are drinking alcohol?
- How often do you have 6 or more alcoholic drinks on one occasion
Each question is scored from 0-4, and unhealthy drinking is >2 for women and >3 for men
How can you classify the complications of alcohol abuse?
- GI = gastric, pancreatic, hepatic
- Cardio = hypertension, arrhythmias, CM
- Neuro = Wernickes, Korsakoff, dementia
- Haem = anaemia, thrombocytopenia
- GU = ED, amenorrhoea
- Other = fractures
What are the cardio red flags?
- Blackouts without warning (Stokes-Adams)
2. Felt dizzy/blacked out whilst exercising (severe AS/HCM)
What is the resp red flag?
Coughing up blood
What are the GI red flags?
- Difficulty swallowing (oesophageal cancer)
- Vomited blood (GI bleeding)
- Blood in stools/black stools (GI bleeding)
- Unexplained weight loss (Colorectal cancer)
What is the GU red flag?
Blood in urine (UT malignancy)
What are the haem red flags?
- Lots of bleeding from small cut (bleeding disorder)
2. Lumps under arm/neck/groin (malignancy)
What are 4 good disease mimickers?
TB
HIV
Syphilis
Sarcoidosis
How do you deal with an emotional response?
NURS Name the emotion Show Understanding Deal with issue with respect Show support
What are common side effects of psychotropics?
Sedation and falls
What are common side effects of diuretics?
Hypokalaemia
Renal dysfunction
Gout
What are common side effects of NSAIDS?
- Exacerbation of HTN
- of HF
- of CKD
What are common side effects of anti-hypertensives?
Postural hypotension and falls
How do you start a clinical examination?
WIPER Wash hands Introduce yourself Position the patient Expose the patient Right side of bed
What are the 6 vital signs?
- HR
- RR
- BP
- Sats
- Temperature
Why is the term scleral icterus misleading?
Bilirubin is actually deposited in the vascular conjunctiva rather than in the avascular sclera
What is a cause of yellow discoloration of the skin, with normal sclerae?
Carotenaemia from eating too many carrots and/or mangoes
What causes deep blue discoloration of the face?
Amiodarone
When is a lipodystrophic facies seen?
Anti-retroviral therapy
When do you see risus sardonicus?
Tetanus
What are 2 features of an acromegalic facies?
Supraorbital ridge and prognathism
What is cyanosis?
Blue discoloration of the skin and mucous membranes due to presence of deoxygenated haemoglobin in superficial blood vessels (approx >50g/L deoxygenated Hb present in capillaries)
Why does cyanosis not occur in anaemic hypoxia?
Because the total Hb content is low
What is central cyanosis?
There is an abnormal amount of deoxygenated blood in the arteries
How can you classify the causes of cyanosis?
Central vs. peripheral
What are the causes of central cyanosis?
- Decreased arterial oxygen saturation
- Polycythaemia
- Hb abnormalities
What are causes of decreased arterial oxygen saturation?
- High altitude
- Hypoventilation
- Lung disease
- R to L cardiac shunt
What is an Hb abnormality that can lead to central cyanosis?
Methaemoglobinaemia, often due to drugs such as dapsone or topical anaesthetics, can be fatal if not recognised and treated
What are causes of peripheral cyanosis?
- All causes of central cyanosis
- Exposure to cold
- Reduced CO (LV Failure/shock)
- Arterial or venous obstruction
What causes pallor?
A deficiency of haemoglobin (anaemia)
At what point does subconjunctival pallor appear?
Hb <70g/L
How can you classify the causes of shock?
- Hypovolaemic
- Cardiogenic
- Distributive
- Obstructive
What are the causes of hypovolaemic shock? x2
- External fluid loss = haemorrhage, vomit, diarrhoea, urine, burns, sweating
- Internal fluid loss = ascites, haemothorax, fracture
What are the causes of cardiogenic shock? x6
- Arrhythmia
- Valve failure
- Cardiomyopathy
- MI
- Dissection
What are the causes of distributive shock? x5
- Anaphylactic
- Neurogenic
- Septic
- Drug-induced
- Addisonian
What are the causes of obstructive shock?
- Tension pnuemothorax
- Tamponade
- PE
How can you classify the complications of obesity? x6
- Endocrine
- Cardio
- Resp
- Gut
- Musk
- Skin
What are some endo complications of obesity?
- T2DM
- Dyslipidaemia
- Amenorrhoea
- Infertility
- PCOS
- Hypogonadism
What are some resp complications of obesity?
- Sleep apnoea
2. Dyspnoea
What are come cardiac complications of obesity?
- HTN
- HF
- IHD
- PE
- Cor pulmonale
What are some musk complications of obesity?
- Arthritis
2. Immobility
What are some skin complications of obesity?
- Abscesses, cellulitis, fungal infections
2. Venous stasis
What are some gut complications of obesity?
- GORD
- NASH
- Hernias
What causes perifollicular haemorrhages?
Vitamin C deficiency
How can you classify dehydration?
- Mild (<5%) = 2.5L deficit
- Moderate (5-8%) = 4L deficit
- Severe (9-12%) = 6L deficit
- Very severe (>12%) = >6L deficit
What are signs of mild dehydration?
- Mild thirst
- Dry mucous membranes
- Concentrated urine
What are signs of moderate dehydration?
+
- Reduced skin turgor
- Tachycardia
What are signs of severe dehydration?
+
- Gaunt face with sunken eyes
- Postural hypotension
- Oliguria (<400ml/24hr)
What are the signs of very severe dehydration?
+
- Comatose
- Moribund
- Signs of shock
What might a pt have if when you shake their hand they are unable to let go?
Dystrophia myotonica
What are 3 causes of blue nails?
- Cyanosis
- Wilson’s disease
- Ochronosis
What is ochronosis?
A syndrome caused by the accumulation of homogentisic acid in connective tissues
What are 2 causes of red nails?
- Polycythaemia (reddish-blue)
2. Carbon monoxide poisoning (cherry-red)
What causes yellow nails?
Yellow nail syndrome
What is yellow nail syndrome?
A rare syndrome also known as “primary lymphedema associated with yellow nails and pleural effusion”
What are causes of splinter haemorrhages?
- Trauma (particularly in manual workers)
- IE
- Vasculitis
What are 3 causes of koilonychia?
- IDA
- Fungal infection
- Raynaud’s disease
What are 3 causes of onycholysis?
- Over-enthusiastic cleaning under the nails
- Thyrotoxicosis
- Psoriasis
What are 3 causes of Beau’s lines?
- Fever
- Cachexia
- Malnutrition
What are Beau’s lines?
Non-pigmented transverse lines in the nail bed, caused by a temporary cessation of cell division in the nail matrix.
What causes leukonychia?
- Hypoalbuminaemia
What are 3 causes of Muehrcke’s lines?
- Trauma
- Hypoalbuminaemia
- Acute illness
What is the difference between Beau’s and Muehrcke’s lines?
Beau’s lines are grooved
What do you call a single transverse white band?
Mees’ lines
What are 2 causes of Mees’ lines?
- Arsenic poisoning
- Renal failure
- Chemotherapy patients
What causes nail fold erythema and telangiectasia?
SLE
What causes Terry’s nails?
- CKD
2. Cirrhosis
What are Terry’s nails?
Also known as ‘half-and-half’ nails, it is when the proximal portion of the nails are white and the distal portion is red-brown
What is onychogryphosis?
Finger or toe nails shaped like a talon
What causes onychogryphosis?
Repeated trauma or fungal infections
How much will very hot weather cause a pts temperature to increase by?
0.5 C
How does body temperature change throughout the day?
There is diurnal variation, coldest in the morning and reaches a peak between 6pm and 10pm, and thus the febrile pattern of most diseases follows this variation
What is hyperpyrexia?
Temp >41.6 C
What is hypothermia?
Temp <35 C
What are 5 causes of hyperpyrexia?
- Heat stroke form exposure
- Excessive exertion e.g. marathon runners
- Malignant hyperthermia
- Neuroleptic malignant syndrome
- Hypothalamic disease
What may cause sweet smelling breath?
- Ketoacidosis
2. Liver failure
What may cause fishy breath?
- Eating fish
2. Uraemic foetor of kidney failure
What are 3 causes of ‘bad breath?’
- Poor dentition
- Gingivitis
- Nasopharyngeal tumours
How can you classify fevers?
- Continued
- Intermittent
- Remittent
- Relapsing
What is a continued fever?
Does not remit e.g. Typhoid, drug
What is an intermittent fever?
Temperature falls to normal each day e.g. pyogenic, lymphoma, miliary TB
What is a remittent fever?
Daily fluctuations >2 C, temperature does not return to normal (not characteristic of any specific disease)
What is a relapsing fever?
Temperature returns to normal for days before rising again
What are 5 causes of a relapsing fever?
- Malaria (tertian = vivax/ovale, quartan = malaria)
- Lymphoma
- Pel-Ebstein of Hodgkin’s lymphoma
- Pyogenic infection
What is meant by a tertian fever?
Fever peaks every other day
What is meant by a quartan fever?
Fever peaks every 3rd day
What is the likelihood ratio?
A useful way to summarise sensitivity and specificity
What is the kappa statistic?
A way of expressing the intra-observer variation for a sign or test
What is the ESC classification for typical angina?
Meets all 3 of
- Characteristic retrosternal chest discomfort
- Provoked by exertion or emotion
- Relieved by rest or GTN or both
What is the ESC classification for atypical angina?
Meets 2 of:
- Characteristic retrosternal chest discomfort
- Provoked by exertion or emotion
- Relieved by rest or GTN or both
What is the ESC classification for non-cardiac chest pain?
Meets 1 or none of:
- Characteristic retrosternal chest discomfort
- Provoked by exertion or emotion
- Relieved by rest or GTN or both
Where would you feel the pain in a proximal aortic dissection?
Anterior chest pain
Where would you feel the pain in a descending aortic dissection?
Interscapular pain
How can you classify the causes of orthopnoea?
Common and uncommon
What is a common cause of orthopnoea?
Cardiac failure
What are the 5 uncommon causes of orthopnoea?
- Massive ascites
- Pregnancy
- Bilateral diaphragmatic paralysis
- Large pleural effusion
- Severe pneumonia
What is oedema that affects the face most likely to be caused by?
Nephrotic syndrome
What is syncope?
Transient loss of consciousness due to cerebral anoxia, usually due to inadequate blood flow
What is presyncope?
Transient sensation of weakness without loss of consciousness
What are two examples of situational syncope?
Micturation and tussive syncope
What are two causes of an exertional syncope?
AS and HOCM
What is a Stokes-Adams attack?
Transient loss of consciousness due to reduced cardiac output
What is a cause of Stokes-Adams attacks?
Complete heart block
What drugs are associated with bradycardias?
- BBs
- Rate limiting CCBs (verapamil, diltiazem)
- DIgoxin
What drugs are associated with QT prolongation?
- Antiarrhythmics = flecainide, amiodarone
- Antibiotics = clarithromycin/erythromycin
- Antipsychotics = chlorpromazine, haloperidol
What drugs are associated with postural hypotension?
- Most anti-HTNs but especially prazosin and CCBs
2. Anti-parkinsonian drugs
What are the 6Ps of acute limb ischaemia?
Pain Pallor Pulseless Perishingly cold Paraesthesia Paralysed
What could cause intermittent claudication in young men/athletes when walking but not with running?
Popliteal artery entrapment syndrome (PAES)
How do you differentiate between lumber canal stenosis (pseudo-claudication) and vascular claudication?
In pseudo-claudication, the pain is not relieved by standing but is relieved by sitting (flexing the spine) and may be exacerbated by extending the spine (e.g. walking downhill)
What are 2 recreational drugs that can cause MI in young people?
Cocaine and amphetamines
What is Thomas Sydenham once say about arteries?
‘A man is as old as his arteries’
Where does the LMS originate from and what are its branches?
- Originates from the left coronary sinus of Valsalva
- LAD supplies anterior wall of heart
- LCX supplies back of heart
Where does the RCA originate from and what are its branches?
- Originates from the right coronary sinus of Valsalva
2. Supplies RV and inferior wall of LV
What is the origin of the word coronary?
From the latin corona, which means garland or crown, as the coronaries look like a garland draped over the heart
What are the 9 common palpable arteries?
- Superficial temporal
- Common carotid
- Brachial
- Radial
- Ulnar
- Femoral
- Popliteal
- Posterior tibial
- Dorsalis pedis
What is a theory explaining clubbing?
PDGF release from megakaryocyte and platelet emboli in the nail beds causes fibrovacular proliferation, thus only occurs in conditions where megakaryocytes and platelets are able to clump in the arterial circulation or bypass the pulmonary circulation
What is the diamond window clubbing sign called?
Schamroth’s sign
What is a way of measuring clubbing?
Interphalangeal depth ratio, ratio >1 = clubbing.
1. AP dimension of finger is measured at DIP and compared with AP dimension where skin joins nail
What are 7 features of Marfans?
- Tall stature
- High arched palate
- Thoracic kyphosis
- Pectus excavatum
- Aortic regurgitation
- Long arms and legs
- Arachnodactyly
What are the cardio causes of clubbing?
Atrial myxoma
Subacute bacterial endocarditis
Cyanotic congenital heart disease
What are the respiratory causes of clubbing?
- Lung caner
- IPF
- CF
- Chronic pulmonary suppuration = bronchiectasis, abscess, empyema.
- Asbestosis, Mesothelioma
What are the GI causes of clubbing?
- Coeliac disease
- IBD
- Cirrhosis
What endo disorder can cause clubbing?
Thyrotoxicosis
What are 2 causes of unilateral clubbing?
- Bronchial AV aneurysm
2. Axillary artery aneurysm
What are tendon xanthomata?
Yellow/orange lipid deposits in the tendons that occur in Type II hyperlipidaemia
What are 2 features of Type III hyperlipidaemia?
Palmar and tuboeruptive (on elbows and knees) xanthomata
What is a pulse deficit?
HR when listening with stethoscope at the heart is greater than pulse felt at the wrist
Does pulse increase or decrease with inspiration?
Increases
Does pulse increase or decrease with expiration?
Decreases
What do you call it when every second heart beat is an ectopic?
Bigeminy
What do you call it when every third heart beat is an ectopic?
Trigeminy
What do you call it when 2 ectopics occur in a row?
Couplet
What is coarctation of the aorta?
A congenital narrowing in the aortic isthmus at the level where the ductus arteriosus joins the descending aorta
What are 4 causes of a radio-radial delay?
- Coarctation of the aorta
- Subclavian artery stenosis
- Dissecting thoracic aneurysm
- Takayasu’s arteritis
What is pulsus alternans?
Alternating strong and weak pulse of advanced LV failure
How many Korotkoff sounds are there?
5
Does BP normally increase or decrease during inspiration?
Decreases