Orthopaedics Mushkies Flashcards
What is the composition of bone?
Cells and Matrix
What cells are bone composed of?
Osteoblasts
Osteoclasts
Osteocytes
OPCs
What kind of matrices are bone composed of?
- Organic (40%) = Osteoid
2. Inorganic (60%)
What is organic bone matrix mainly composed of?
Collagen Type I
What is the main function of organic bone matrix?
Resists tension, twisting and bending
What is inorganic bone matrix mainly composed of?
Calcium hydroxyapatite
What is the main function of inorganic bone matrix?
Resists compressive forces
How can you classify the types of bone?
Woven bone and Lamellar Bone
What is woven bone?
Disorganised bone that forms the embryonic skeleton and fracture callus
What is lamellar bone?
Mature bone that can be of two types
What are the 2 types of lamellar bone?
- Cortical/compact = dense outer layer
2. Cancellous/trabecular = porous central layer
What are the two ways in which bone is formed?
- Intramembranous ossification
2. Endochondral ossification
What is intramembranous ossification?
Direst ossification of mesenchymal bone models formed during embryonic development e.g. skull bones, mandible and clavicle
What is endochondral ossification?
- Mesenchyme –> cartilage –> bone
2. Most bones ossify this way
What are the 3 phases of fractuer healing?
- Reactive phase
- Reparative phase
- Remodelling phase
What is the reactive phase of fracture haling?
- Injury - 48hrs
- Bleeding into # site –> haematoma
- Inflammation –> cytokine, GF and vasoactive mediator release –> recruitment of leukocytes and fibroblasts –> granulation tissue
What is the reparative phase of fracture healing?
- 2 days - 2 weeks
- Proliferation of osteoblasts and fibroblasts –> cartilage and woven bone production –> callus formation
- Consolidation (endochondral ossification) of woven bone into lamellar bone
What is the remodelling phase of fracture healing?
- 1 week - 7 years
2. Remodelling of lamellar bone to cope with mechanical forces applied to it (Wolff’s law = form follows function)
What is Wolff’s law?
Form follows function, i.e. bone in a healthy person will adapt to the loads under which it is placed
What kind of fractures have a healing time of 3 weeks?
- Closed
- Paediatrics
- Metaphyseal
- Upper limb
What complicating factors double healing time?
ALDO
- Adult
- Lower limb
- Diaphyseal
- Open
How can you classify fractures?
- Traumatic
- Stress
- Pathological
How can you classify traumatic fractures?
- Direct = assault with metal bar
- Indirect = FOOSH –> clavicle #
- Avulsion
What causes a stress fracture?
Bone fatigue due to repetitive strain e.g. foot #in marathon runners