Tagnawa And Sirmata BSWR (Pathology) Flashcards
Uterus during pregnancy?
a. Anaplasia
b. Hyperplasia
c. Atrophy
d. Metaplasia
e. All of the above
b. Hyperplasia
Cellular adaptation in papillomavirus infection?
a. Anaplasia
b. Hyperplasia
c. Atrophy
d. Metaplasia
e. Hypertrophy
b. Hyperplasia
What is the risk of rupture for an aneurysm measuring 5.5 cm?
a. 1%
b. 11%
c. 20%
d. 25%
b. 11%
A 49 year old had a heartburn for 10 years. Biopsy done revealed glandular changes in the distal epithelium of the esophagus. What is this cellular adaptation?
a. Anaplasia
b. Hyperplasia
c. Atrophy
d. Metaplasia
e. Hypertrophy
d. Metaplasia
The most common cause of cellular injury in clinical medicine?
a. Caseous necrosis
b. Ischemia
c. Apoptosis
d. Autophagy
b. Ischemia
Which of the following is responsible for lymphocyte rolling?
a. Selectins
b. Cytokines
c. ICAM
d. PECAM
e. All of the above
a. Selectins
Which among the following components of the vessel wall is responsible for the capability of blood vessels to expand and recoil?
a. Elastin
b. Collagen
c. Glycosaminoglycan
d. Endothelial cells
a. Elastin
Which of the following is the most important staging factor for malignant tumors?
a. Histologic grade of the tumor
b. Proliferative capacity of the tumor cells
c. Tumor cell karyotype
d. Metastases to regional lymph nodes
d. Metastases to regional lymph nodes
Cytogenetic studies in a patient with chronic myelogenous leukemia (CML) demonstrate a t(9;22) chromosomal translocation. Which of the following best explains the pathogenesis of this tumor?
a. Expansion of trinucleotide repeat
b. Altered DNA methylation status
c. Proto-oncogene activation
d. Enhanced expression of telomerase gene
c. Proto-oncogene activation
Tumor suppressor gene altered in the majority of cancers.
a. STK1
b. APC
c. RB
d. P53
d. P53
A 6-month-old girl has a palpable mass on the left side of her abdomen. Urinalysis shows high levels of vanillylmandelic acid. A CT scan reveals an abdominal tumor and bony metastases. The primary tumor is surgically resected and on histologic studies, the specimen discloses neuroblastoma. Evaluation of the N-myc protooncogene in this child’s tumor will most likely demonstrate which of the genetic changes?
a. Chromosomal translocation
b. Exon deletion
c. Expansion of trinucleotide repeat
d. Gene amplification
d. Gene amplification
A tumor marker useful for breast cancer:
a. CA-125
b. CA-19-9
c. CA-15-3
d. AFP
c. CA-15-3
Alpha-fetoprotein antigen is a tumor marker used in:
a. Liver cell cancer
b. Prostate cancer
c. Ovarian cancer
d. Lung cancer
a. Liver cell cancer
Occupational exposure to this compound is linked to the development of acute myeloid leukemia.
a. Benzene
b. Vinyl chloride
c. BPA
d. Dioxin
a. Benzene
Which of the following is NOT TRUE of the effects of alcoholism on cellular processes?
a. Depletion of NAD impairs fatty acid oxidation leading to steatosis
b. Depletion of NAD impairs conversion of lactate to pyruvate leading to acidosis
c. Reactive oxygen species derived from alcohol metabolism causes lipid peroxidation of hepatocyte membranes
d. Acetaldehyde triggers enterotoxin release from gram-negative bacteria
d. Acetaldehyde triggers enterotoxin release from gram-negative bacteria
Overdose with acetaminophen can be treated by:
a. N-acetylcysteine
b. Naloxone
c. Thiamine
d. Activated charcoal
a. N-acetylcysteine
Peak sensitivity on developing embryo to teratogenic insult occurs in what week?
a. 0-3
b. 4-5
c. 9-10
d. 28-32
b. 4-5
Which of the following fetal growth restriction is most likely to result in asymmetric growth restriction with relative sparing of the brain.
a. Single umbilical artery
b. Trisomy 18
c. Congenital syphilis
d. Congenital rubella
a. Single umbilical artery
PE of a child revealed holosystolic murmur, weak pulses in the lower extremities, hypertension in the upper extremities and notch on the ribs. Which of the following congenital heart defects is most likely?
a. Coarctation of the aorta
b. Patent ductus arteriosus
c. Tetralogy of fallot
d. Pulmonary stenosis
a. Coarctation of the aorta
Which of the following structures of the heart is most susceptible to ischemia?
a. Endocardium
b. Subendocardium
c. Pericardium
d. Sub-pericardium
b. Subendocardium
Which of the following diseases has an MCV of >100
a. Thalassemia
b. Iron deficiency anemia
c. Pernicious anemia
d. G6PD
c. Pernicious anemia
Endothelial lined channel responsible for the exchange of diffusible substances between blood and tissue
a. Arteriole
b. Postcapillary venule
c. Capillary
d. Lymphatics
c. Capillary
Which among the chemicals are associated with the development of angiosarcoma?
a. Betel nut
b. Naphthylamine
c. Polyvinyl chloride
d. Dimethylaminoazobenzene
c. Polyvinyl chloride
It is considered as the most common cause of hypertension.
a. Cardiovascular diseases
b. Neurologic
c. Endocrine
d. Essential hypertension
d. Essential hypertension
In response to hypoperfusion of organs, the kidneys produce this proteolytic enzymes which helps regulate blood pressure:
a. Renin
b. ACE
c. Nitric oxide
d. ANP
a. Renin
In the pathogenesis of atherosclerosis, the first event that takes place is _____
a. Lipid accumulation
b. Platelet adhesion
c. Calcification
d. Endothelial injury and dysfunction
d. Endothelial injury and dysfunction
What is the most common form of hemangioma?
a. Pyogenic granuloma
b. Capillary hemangioma
c. Cavernous hemangioma
d. Juvenile hemangioma
b. Capillary hemangioma
The following are characteristics of a stable plaque, except:
a. Thick fibrous cap
b. High collagen content
c. Minimal inflammation
d. Large lipid core
d. Large lipid core
A 60/M came to the OPD with intense facial pain and headache particularly on the temporal region. Symptoms are accompanied by fever, fatigue and weight loss. Upon physical examination, the temporal artery is tender upon palpation. What is the most likely diagnosis?
a. Giant cell arteritis
b. Takayasu arteritis
c. Polyarteritis nodosa
d. Microscopic polyangiitis
a. Giant cell arteritis
Causative agent of Kaposi Sarcoma.
a. HHV8
b. HTLV1
c. EBV
d. NOTA
a. HHV8
In response to hypoperfusion of organs, the kidneys produce this proteolytic enzyme which helps regulate blood pressure
a. Renin
b. Angiotensin converting enzyme
c. Nitric oxide
d. ANP
a. Renin
The most common location of aneurysm secondary to atherosclerosis
a. Abdominal aorta
b. Thoracic aorta
c. Common carotid artery
d. Mesenteric artery
a. Abdominal aorta
It is a form of vasculitis associated with hepatitis B infection.
a. Kawasaki disease
b. Takayasu disease
c. Polyarteritis nodosa
d. Buerger’s disease
c. Polyarteritis nodosa
Which type of aortic dissection involves the ascending aorta only?
a. Debakey I
b. Debakey lI
c. Debakey III
d. A and B are correct
b. Debakey lI
A form of vasculitis presenting with asthma, allergic rhinitis with lung infiltrate, and eosinophilic infiltration of vessels and tissues.
a. Churg-strauss syndrome
b. Granulomatosis with polyangiitis
c. Microscopic polyangiitis
d. Kawasaki disease
a. Churg-strauss syndrome
A 2-year-old male with fever and mucosal bleeding revealed a complete blood count of marked leukocytosis. On blood film, numerous atypical cells were noted suggestive of leukemic process, hence, bone marrow biopsy was done. Bone marrow core biopsy revealed hypercellular marrow packed with an enlarged cell (larger than BC) with fine nuclear chromatin, small and less conspicuous nucleoli and scant cytoplasm. Immunophenotyping revealed TDT, (+), myeloperoxidase (-), CD19 (+), CD10 (+), Pax5 (+). What is the diagnosis of the case?
a. T-ALL
b. B-ALL
c. CML
d. CLL
b. B-ALL
With this case, the following are good prognostic markers, EXCEPT:
a. Presence of t(12;21)
b. Hyperdiploidy
c. Low cell count
d. MYC amplification
d. MYC amplification
On cytogenetics, such translocation may be observed in this disease:
а. t(12;21)
b. t(9;22)
c. Both a and b
d. Neither a nor b
c. Both a and b
Neoplastic cells in non-classical Hodgkin lymphoma is usually described as:
a. Infolded nuclear membranes, small nucleoli, chromatin and abundant pale cytoplasm
b. Two nuclear lobes, large inclusion like nucleoli and abundant cytoplasm
c. Mononuclear
d. Folded or multilobulated nucleus and lies within an open space
d. Folded or multilobulated nucleus and lies within an open space
The diagnosis of AML is based on the presence of:
a. At least 20% myeloid blasts in the bone marrow
b. At least 20% myeloid blasts with auer rods in the bone marrow
c. At least 10% myeloid blasts in the bone marrow
d. At least 10% myeloid blasts with auer rods in the bone marrow
a. At least 20% myeloid blasts in the bone marrow
All of the following are leading causes of death among infants, EXCEPT:
a. SIDS
b. Tumors
c. Prematurity
d. Congenital malformations
b. Tumors
Fetal growth restriction is mostly due to
a. Fetal abnormalities
b. Placental abnormalities
c. Maternal abnormalities
d. All of the above
d. All of the above
This is true of pulmonary surfactant:
a. Production by type II pneumocytes is accelerated after the 35th week of gestation
b. Predominantly composed of dipalmitoylphosphatidylcholine.
c. Both a and b
d. Neither a nor b
c. Both a and b
Fetal hydrops can be due to the following, EXCEPT:
a. Immune hemolytic anemia
b. Twin to twin in utero transfusion
c. Non immune hemolytic anemia
d. Cytomegalovirus infection
c. Non immune hemolytic anemia
All of the following are components of Wilms tumor, EXCEPT:
a. Immature glomeruli
b. Immature renal tubules
c. Blastemal component
d. Lymphoblastic component
d. Lymphoblastic component
A 38 y/o primigravida has premature rupture of membranes at 36 weeks gestation, necessitating delivery. At birth, the infant is noted to have a two vessel umbilical cord, a cleft lip, a heart murmur and spina bifida. Which of the following factors is most likely to increase the risk of hyaline membrane disease in the infant?
a. Chorioamnionitis
b. DM, type 1
c. Maternal corticosteroid therapy
d. Oligohydramnios
b. DM, type 1
The hyperinsulinism in the fetus of a diabetic mother suppresses pulmonary surfactant production. Corticosteroids stimulate surfactant production in type II pneumocytes. Infection may increase the risk of premature birth, but it does not significantly affect surfactant production. The risk for major malformations, called diabetic embryopathy, is 6% to 10% in infants born to mothers with diabetes mellitus; but there is no set pattern to the anomalies, and similar embryopathies are not seen in gestational diabetes. So the cause for anomalies here is unknown. Macrosomia is the result of growth-promoting effects of insulin in the fetus. Oligohydramnios leads to constriction in utero that culminates in pulmonary hypoplasia, not decreased surfactant. Maternal hypertension may reduce placental function and increase growth retardation, but it typically does not have a significant effect on the production of surfactant.
Physical examination of a newborn revealed microcephaly, frontal bossing, long and narrow forehead, maxillary and mandibular hypoplasia, narrow palpebral fissures, thin elongated philtrum. Ocular problems include microphthalmia, corneal clouding, coloboma and proptosis, A systolic murmur is heard auscultation and echocardiography revealed ventricular septal defect. Which of the following conditions is most likely to produce these findings?
a. Congenital rubella
b. Fetal alcohol syndrome
c. Maternal diabetes mellitus
d. Trisomy 21
b. Fetal alcohol syndrome
Alcohol is one of the most common environmental teratogens affecting fetuses, although the effects can be subtle. There is no threshold amount of alcohol consumption by the mother to produce fetal alcohol syndrome; no amount is safe. Children with fetal alcohol syndrome tend to be developmentally impaired throughout childhood, but the physical anomalies tend to become less apparent as the child matures. Vertebral abnormalities, including scoliosis, can be present. The liver can have fatty metamorphosis with hepatomegaly and elevated serum transaminases. The major effects of congenital rubella occur during organogenesis in the first trimester and result in more pronounced defects, including congenital heart disease. Maternal diabetes often results in a larger infant, and malformations may be present. Placenta previa, a low-lying placenta at or near the cervical os, can cause significant hemorrhage at the time of delivery or uteroplacental insufficiency with growth retardation before delivery. Placental causes of intrauterine growth retardation result in asymmetric growth retardation with sparing of the brain. The findings of trisomy 21 are subtle at birth, but typically include brachycephaly, not microcephaly.
The process of migration of leukocytes through the endothelium is?
a. Opsonization
b. Transmigration chemotaxis
c. Margination
d. All of the above
b. Transmigration chemotaxis
Accumulation of fluid in body cavities.
a. Edema
b. Effusion
c. Exudate
d. Transudatez
b. Effusion
Laboratory test that assess the function of the coagulation factors in the intrinsic pathway (factors XII, XI, IX, VIII, X, V, Il, and fibrinogen)
a. D-Dimer
b. Prothrombin time (PT)
c. Partial thromboplastin time (PTT)
d. Thrombin time
c. Partial thromboplastin time (PTT)
Virchow triad include:
a. Endothelial injury, stasis, hypercoagulability
b. Epithelial injury, stasis, hypercoagulability
c. Endothelial injury, stasis, hypersensitivity
d. Endothelial injury, turbulence, hypocoagulability
a. Endothelial injury, stasis, hypercoagulability
Most common cause of acute gastric ulcer:
a. Helicobacter pylori infection
b. NSAID use
c. Smoking
d. Alcohol intake
b. NSAID use
A 35-year-old, HIV-positive man complains that he has had a “bad” taste in his mouth and discoloration of his tongue for the past 6 weeks. On physical examination, there are areas of adherent, yellow-tan, circumscribed plaque on the lateral aspects of the tongue. This plaque can be scraped off as a pseudomembrane to show an underlying granular, erythematous base. What is the most likely diagnosis?
a. Aphthous ulcer
b. Hairy leukoplakia
c. Glossitis
d. Oral thrush
d. Oral thrush
Least likely of the Non-proliferative breast disease
a. It includes common morphologic alterations that are often grouped under the term fibrocystic changes
b. They are not associated with an increased risk of breast cancer
c. It includes intraductal papilloma
d. Consists of three principal morphologic changes (fibrosis, cysts, adenosis)
c. It includes intraductal papilloma
Most common, location of pilocytic astrocytoma.
a. Cerebellum
b. Cerebral hemisphere
c. Spinal cord
d. Optic nerve
a. Cerebellum
This tumor arises from the meningothelial cells of the arachnoid.
a. Meningioma
b. Medulloblastoma
c. Gangliogliomas
d. Choroid plexus papillomas
a. Meningioma
A congenital immune deficiency syndrome characterized by the loss of T cells with a particular susceptibility to Candida sp. infections.
a. DiGeorge syndrome
b. Cushing syndrome
c. Conn syndrome
d. Wiskott-Aldrich syndrome
a. DiGeorge syndrome
Patient manifest with hypertension that is resistant to antihypertensive therapy, sudden attacks of dizziness, blurred vision, and excruciating headaches. A 24-hour urinalysis reveals increased metanephrines.
a. Diabetes mellitus
b. Cushing syndrome
c. Pheochromocytoma
d. Pituitary adenoma
c. Pheochromocytoma
Characteristics of melanoma, except:
a. A = asymmetric
b. B = border is irregular
c. C = color is variable
d. D = diameter is < 6 mm
E. E = exposure history to UV light
d. D = diameter is < 6 mm
The most important cause of cutaneous squamous cell carcinoma is DNA damage induced by:
a. HPV infection
b. Cigarette smoking
c. UV light exposure
d. Alcohol
c. UV light exposure