T4-Osteoporosis

Question 1

Where do osteoclasts and osteoblasts originate from?

Answer 1

Bone marrow

Question 2

What do osteoclasts do?

Answer 2

Chew up bone cells

Question 3

What do osteoblasts do?

Answer 3

Build new bone cells

Question 4

When we take an osteoporosis medication, what are we wanting to block: osteoclasts or osteoblasts?

Answer 4

OSTEOCLASTS–less chewing up of the bone!!

Question 5

What are the 2 osteoporosis drugs?

Answer 5

Biphosphonates

Raloxifene

Question 6

What are the 3 biphosphonates?

Answer 6

All end in DRONATE
Alendronate
Ibandronate
Risedronate

Question 7

Which biosphonate is PO and IV?

Answer 7

Ibandronate

Question 8

Biophosphonates are very irritating to the ___.

Answer 8

GI tract

Question 9

What are the adverse effects of biophosphonates? (5)

Answer 9

-Heartburn
-Abdominal pain
-Diarrhea
^*remember, very irritating to GI tract
-HYPOcalcemia
-Osteonecrosis of the jaw (ONJ)

Question 10

What is the client teaching with biophosphonates?

Answer 10

1. Take in the AM
2. COMPLETELY empty stomach (no coffee, no multivitamin, NOTHING)
3. Take with FULL glass of water
   - Stay upright for 30-60 minutes (extremely irritating to the GI tract [esophagus included], so do not lay down/recline!)

Question 11

Raloxifine increases _____

Answer 11

Bone density

Question 12

What are the other benefits of raloxifine besides increasing bone density? (3)

Answer 12

1. Mimics estrogen in bones (estrogen helps with building of the bone)
2. Blocks estrogen (uturus and breasts)
3. Decreases cancer risk

Question 13

What are the 3 adverse effects of Raloxifine?

Answer 13

1. Hot flashes
2. Leg cramping
3. Weight gain, edema

Question 14

What are the 2 BBW of Raloxifine?

Answer 14

1. Thromboembolism (DVT, PE)–which can lead to: 2. Stroke

Question 15

Because inactivity promotes DVT, patients should discontinue Raloxifine at least ___ before prolonged immobilization (post surgery, extended bed rest, and should not resume the drug until ____ has been restored.

Answer 15

72 hours; full mobility

Question 16

Patients should minimize periods of restricted activity if taking Raloxifine when traveling. How do you do this?

Answer 16

If you are on a 15 hour plane ride, then you need to minimize periods of restricted activity by getting up and walking up and down the aisle of the airplane periodically,