T4-Gout Flashcards
What is the patho of gout?
DNA converted to Hypoxathine. Hypoaxanthine is converted to Xanthine by the Xanthine Oxidase enzyme. Xanthine is converted to Uric acid by the Xanthine Oxidase enzyme
Why do people have gout?
Making too much uric acid or not releasing [getting rid] of the uric acid well enough
Uric acid is not _____ so it will ____ (due to cold temperature)
NOT water soluble; it will crystalize
Where do we usually see gout?
The joint of your feet due to gravity and cold temp
What drug do you take if you have a gouty attack?
NSAID or glucocorticoid
What drug do you take if you have gout more often throughout the year?
Allopurinol
Colchicine
What is the MOA of Allopurinol?
Allopurinol will block XO so hypoxanthine won’t end up becoming uric acid.
*Hypoxanthine is water soluble –so easily excreted
Allopurinol is the ____ of gout treatment. It is a urate ___ drug.
Cornerstone; urate lowering drug
Allopurinol is for gout ____ and ____
Prevention and treatment
Allopurinol gets its full effect in ____
1-2 months
What is the goal of allopurinol?
Get uric acid below 6mg/dL
Allopurinol is indicated for certain cancers. Why would people with cancer take this drug?
Chemo causes cells to break and release DNA…
Remember DNA is converted to hypoxathine, which is converted to xanthine via XO. Xanthine is converted to uric acid via XO.
If too much DNA is being released then the uric acid forming process is occurring more frequently, causing gout in cancer patients!
What are the adverse effects of allopurinol?
- Acute gouty attack–give NSAID
- Hypersensitivity syndrome rare, but if it happens, STOP THE DRUGS (amoxicillin and allopurinol can cause this)
- Hepatotoxicity (RARE)
What is the MOA of Colchicine?
Poorly understood; but something to do with the production and reproduction of WBC
Colchicine is for gout ____ and ___
Prevention and treatment
