T4-HSV Flashcards
What is an early sign of HSV?
Tingling
What is HSV?
Vesicular lesions [crusts] that lie dormant in nerves
Where is HSV1?
Face, eyes, CNS, mouth
Where is HSV2?
Genitalia
What is eczema herpeticum?
Hemorrhagic crusts and vesicles due to herpes simplex virus infection that are present on the face of infants with underlying attic dermatitis
What are the 2 HSV meds?
Acyclovir
Valacyclovir
Which one is PO only?
Valacyclovir
Which is PO or IV?
Acyclovir
What is the difference and the MOA of valcyclovir and acyclovir?
Valacyclovir has an extra part to its structure that allows it to get absorbed easier. Once it is absorbed, the extra part has been “chopped off” and it essentially becomes acyclovir. At his point the drug is only going to activate if it finds an infected cell. If it finds an infected viral cell, then it will cause DNA termination.
Which HSV drug requires a higher dose?
Acyclovir–it doesn’t get absorbed as easily, so you need more of it and more doses for it to work (when given PO, that is)
What are the adverse effects of acyclovir and valcyclovir?
Very well tolerated
Headache
N/V
Phlebitis (IV acyclovir)
What are the RARE adverse effects of acyclovir and valcyclovir?
Crystal urea (kidneys) Altered mental status
Crystal urea is increased by _____. Client teaching?
Dehydration–drink lots of H20! Stay hydrated!!!
How do we handle care for a pregnant mother with HSV2 and the delivery of her baby?
Give PO acyclovir or valacyclovir !
What if a pregnant mother with HSV2 is going into labor and she has an active outbreak?
Deliver C section!
How can we treat eczema herpeticum and encephalitis?
IV acyclovir
How can we treat recurrent, painful HSV2 outbreaks?
PO therapy of Valacyclovir
How can we treat shingles?
PO Acyclovir or Valacyclovir
Client teaching: when do we need to tell our client they need to come in/start medication if they have HSV outbreaks: when it is tingling or when it is a lesion?
Tingling
Client teaching: Do the meds for HSV cure the patient?
NO; not a cure, still contagious
Client teaching: why do we need to tell our clients to drink plenty of H20?
To prevent crystal urea in the kidneys!
Which HSV med is more expensive?
Valacyclovir
