T4-HSV

Question 1

What is an early sign of HSV?

Answer 1

Tingling

Question 2

What is HSV?

Answer 2

Vesicular lesions [crusts] that lie dormant in nerves

Question 3

Where is HSV1?

Answer 3

Face, eyes, CNS, mouth

Question 4

Where is HSV2?

Answer 4

Genitalia

Question 5

What is eczema herpeticum?

Answer 5

Hemorrhagic crusts and vesicles due to herpes simplex virus infection that are present on the face of infants with underlying attic dermatitis

Question 6

What are the 2 HSV meds?

Answer 6

Acyclovir

Valacyclovir

Question 7

Which one is PO only?

Answer 7

Valacyclovir

Question 8

Which is PO or IV?

Answer 8

Acyclovir

Question 9

What is the difference and the MOA of valcyclovir and acyclovir?

Answer 9

Valacyclovir has an extra part to its structure that allows it to get absorbed easier. Once it is absorbed, the extra part has been “chopped off” and it essentially becomes acyclovir. At his point the drug is only going to activate if it finds an infected cell. If it finds an infected viral cell, then it will cause DNA termination.

Question 10

Which HSV drug requires a higher dose?

Answer 10

Acyclovir–it doesn’t get absorbed as easily, so you need more of it and more doses for it to work (when given PO, that is)

Question 11

What are the adverse effects of acyclovir and valcyclovir?

Answer 11

Very well tolerated
Headache
N/V
Phlebitis (IV acyclovir)

Question 12

What are the RARE adverse effects of acyclovir and valcyclovir?

Answer 12

Crystal urea (kidneys)
Altered mental status

Question 13

Crystal urea is increased by _____. Client teaching?

Answer 13

Dehydration–drink lots of H20! Stay hydrated!!!

Question 14

How do we handle care for a pregnant mother with HSV2 and the delivery of her baby?

Answer 14

Give PO acyclovir or valacyclovir !

Question 15

What if a pregnant mother with HSV2 is going into labor and she has an active outbreak?

Answer 15

Deliver C section!

Question 16

How can we treat eczema herpeticum and encephalitis?

Answer 16

IV acyclovir

Question 17

How can we treat recurrent, painful HSV2 outbreaks?

Answer 17

PO therapy of Valacyclovir

Question 18

How can we treat shingles?

Answer 18

PO Acyclovir or Valacyclovir

Question 19

Client teaching: when do we need to tell our client they need to come in/start medication if they have HSV outbreaks: when it is tingling or when it is a lesion?

Answer 19

Tingling

Question 20

Client teaching: Do the meds for HSV cure the patient?

Answer 20

NO; not a cure, still contagious

Question 21

Client teaching: why do we need to tell our clients to drink plenty of H20?

Answer 21

To prevent crystal urea in the kidneys!

Question 22

Which HSV med is more expensive?

Answer 22

Valacyclovir