T Cells Flashcards
what is the major problem is Di George’s syndrome
no thymus
what cells express MHC I and II molecuels
Thymic epethelial cells, B cells, and APC
where do immature T cells enter the thymus
cortico medullary junction
do B or T cells have more junctional diversity?
T cells
_____ and _____ are expressed in DN thymocytes
RAG and TDT
medullary thymus epethelial cells (mTEC) express
AIRE
defeciency of AIRE causes
APECED
where does central tolerance occur
primary lymphoid organs
which cells induce Treg
CD4
expression of what induces Treg
FoxP3
if FOXp3 is imparied, what condition occurs
IPEX
deficiency of AIRE and FOXP3 leads to what type of disorders
autoimmune
Beta rearrangemnet, pre TCR alpha leads to
proliferation in DN thymocyte
TCR complex includes
CD3
CD4 and CD8 are examples of
coreceptors
