Antigen Recognition Flashcards
1
Q
what is the exception of MHC recognition
A
superantigens
2
Q
what are B cell superantigens
A
staphlyococcal protein A; HIV
3
Q
what are the T cell superantigens
A
S. aureaus, S. pyogenes
4
Q
where does b cell superantigen bind
A
Fab regions
5
Q
where does T cell superantigen bind
A
VB domain
6
Q
what are the three signals in antigen recognition
A
- antigen recognition
- costimulation
- differentiaion cytokines
7
Q
what are the costim molecules on APC
A
CD80 and CD86
8
Q
what are the costim receptors on T cells
A
CD28
9
Q
what does cd28 do
A
promote T cell proliferation
10
Q
what is the B cell costim
A
CD40
11
Q
are antigenic but not immunogenic
A
haptens
12
Q
enhance immunogenicity of antigen/immunogen
A
adjuvents
13
Q
B cells primary recognize
A
polysaccharides
