Antigen Presentation Flashcards
Are MHC/HLA molecules polygenic or polymorphic
Both and have codominant expression
B2 Microglobulin is necessary for stability of
MHC class I molecule
What do MHC I antigens process
Endogenousd
What are the source of peptides for MHC I
Proteasomes, TAP, peptide loading complex
What is the primary source of class II MHC
Exogenous
What is the effect of IFN gamma on MHC II
Unregulates transcription
If you don’t hav TAP, what immmune system may be missing
Class I, CD8
Which class uses invariant chain to provide stability
Class II
A region of DNA taht encodes a group of molecules that recognize an antigen
MHC
Class II has ___ transmembrane domains
2
what is necessary for T cell killing
specific peptide and slef MHC
DC secrete what to stimulate Th1
IL-12
MHC-II fights _______ pathogens
extracelluar
what blocks peptide binding groove in the production of MHC-II
invariant chain
where is MHC-I expressed
any nucleated cell
how do peptides enter the ER in MHC-I
TAP transporter
How does MHC I and II break down foreign material
MHC-1: proteasome
MHC-II: lysosome
where does DC react with Th
paracortex
where are B cells found in lymph nodes
cortex (follicles)
what is signal 1
when a TCR and MHC match
what is signal 2?
When Co stim match (Cd80 or CD86)
what are the encapsulated bacteria
streptococcal, meningococcal, and Hib
Fc portion is part of which chainm
heavy
what is involved in passive immunization
IgG
