Anatomy Of Immune System Flashcards
IL-7 produces what kind of cell
T cell
IL-15 produces what type of cell
Natural killer cell
What do common gamma chains do
They are receptors for the interleukins
Where it’s the gene for the gamma chain located
X chromosome
What it’s the indication for SCID
Absence of T cells
Measure the total immunoglobulin tigers in serum
Nephelometry
Measures specific immunoglobulins or antigens in serum
ELISA
Assesses presence of tissue antigens or serum immunoglobins
Immunofluoresccence
Assesses presence and phenotype of peripheral blood or tissues
Flow cytometry
In flow cytometry of SSC vs FSC, what would be in the far left corner? What about far right
Granulocytes, monocytes
What are the self antigens fo T helper cells
CD4, TCR, CD3, CD28, MHC1
What are the self antigens of CTL
CD8, TCR, CD3, CD28, MHC
What are the self antigens of B cell
BCR, MHC I, MHC II, CD20, CD19, CD40
MACROPHAGES AND DENDRITIC CELLS EXPRESS
MHC I AND MHC II
What are the costimulatory molecules on Macrophages and Denderitic cells
CD 80 and CD86
What is used to identify NK on flow cytometry
CD56
What is the effect of MHC I receptors on NK cells
Raises threshold for activation
What do activated NK secrete
IFN-gamma (Th1)
CD56 is associated with what cells
Natural Killer Cells
IFN-gamma stimulates the cell with what surface markers
MHC-1
What cells are going to still be present in a gamma chain deficiency
B cells (nonfunctional)
What deficiency is associated with the absence of all lymphocytes
ADA
What does the gamma chain receptor do?
Respond to Il-7 and IL-15
What do CD80 and CD86 bing to
CD28
