T-Cell Migration Receptors/Ligands

Question 1

TCR (Location, Function, Ligand, Ligand location)

Answer 1

• T-Cell
• Antigen recognition
• MHC-I or II
• APCs, all nucleated cells (MHC-I)

Question 2

CD4/CD8 (Location, Function, Ligand, Ligand location)

Answer 2

• Tcell
• signal transduction
• MHC-I or II
• APCs, all nucleated cells (MHC-I)

Question 3

CD3 (Location, Function, Ligand, Ligand location)

Answer 3

• Tcell

- Signal transduction (costimulatory)

Question 4

CD28 (Location, Function, Ligand, Ligand location)

Answer 4

• TCell
• signal transduction (costimulatory) — causes release of IL-12 from APCs
• CD80 (B7)
• APCs

Question 5

CTLA-4 (Location, Function, Ligand, Ligand location)

Answer 5

• Tcell
• Inhibitor
• CD80 B7
• APCs

–Present on T-regs along with CD25

Question 6

PD-1 (Location, Function, Ligand, Ligand location)

Answer 6

• Tcell
• Inhibitor
• PD-I ligand
• APCs, tumors, tissue cells

Question 7

L-Selection (Location, Function, Ligand, Ligand location)

Answer 7

• Tcell
• Weak binding of the T-cell to the HEV (high endothelium venules)
• L-selection ligand
• HEV (peripheral lymph)

Question 8

LFA-1 (Location, Function, Ligand, Ligand location)

Answer 8

• Tcell
• Adhesion surface protein that causes ARREST of Tcell on HEV
• I-CAM
• HEV (Peripheral lymph)

Question 9

CCR7 (Location, Function, Ligand, Ligand location)

Answer 9

• Tcell
• recruits lymphocytes to lymph, unregulated by Dendritic cells following DC activation
• CCL-19, CCL-21

Question 10

E + P Selectin (Location, Function, Ligand, Ligand location)

Answer 10

• Periphery endothelial cell (PEC)
• weak binding of Tcell to PEC wall
• E + P selectin ligand
• T cell

Question 11

LFA-1 + VLA-4

Answer 11

• Tcell
• ARREST Tcell on PEC
• I-CAM, V-CAM (respectively)
• PEC

(misc. — Beta2 integrin; Beta1 integrin, respectively)

Question 12

CXCR3

Answer 12

• Tcell
• Activates/increases integrin affinity during binding
• CXCL-10, others
• PEC