Interleukins & Other Mediators

Question 1

IL-10 (source, target, local/systemic effects)

Answer 1

• T cells
• Anti-inflammatory cytokine
• Inhibition of cytokines and chemokines, target dendritic cells and macrophages

Question 2

TGF-B *(source, target, local/systemic effects)

Answer 2

• Anti-inflammatory cytokine

- Target T-cells, stop inflammation

Question 3

IL-1 (source, target, local/systemic effects)

Answer 3

-Macrophages, dendritic, Mast
Local: lymphocytes, vascular endothelium permeability

Systemic
-Fever, IL-6 production

Question 4

TNF-alpha (source, target, local/systemic effects)

Answer 4

-Tumor Necrosis Factor
-Macrophages, TCells, Mast Cells
Local: Increase vascular permeability to let IgA into tissues, neutrophil activation

Systemic

- Fever, shock, metabolic mobilization - acute phase protein response

Question 5

IL-6 (source, target local/systemic effects)

Answer 5

Local
-Lymphocyte activation, antibodies, B-cell differentiation

Systemic
-Fever, acute phase protein production

Question 6

IL-8 (source, target, local/systemic effects)

Answer 6

-T cells, macrophages
-Granulocytes
Local Only
-Recruits neutrophils, basophils, T Cell to infection
-Acts as a chemotaxis

Question 7

IL-12 (source, target, local/systemic effects)

Answer 7

-Macrophage
-T cells
Local Only
-Activates NK cells, induces transition of CD4 TCalls into THelper cells

Question 8

IL-7 (source, target, local/systemic effects)

Answer 8

• Lymphocytes
• B & T Cells
• Stimulates the creation of immature immune cells

Question 9

IL-9 (source, target, local/systemic effects)

Answer 9

• T Cells
• T Cells
• Enhancing T cell and Mast Cell growth

Question 10

IL-11 (source, target, local/systemic effects)

Answer 10

• Bone marrow
• Hepatocytes
• Synthesis of APP

Question 11

IL-4 (source, target, local/systemic effects)

Answer 11

• T Cells
• B and T cells
• Stimulates B cell growth factor

Question 12

IL-2 (source, target, local/systemic effects)

Answer 12

• T cell
• T cells
• Stimulates T cell growth factor

Question 13

IL-3 (source, target, local/systemic effects)

Answer 13

• T-Cells
• Bone Marrow cells
• Stimulate bone marrow growth

Question 14

IL-13

Answer 14

-Activated macrophages in alternative pathway