T cell-Mediated Immunity Flashcards
What is CCR7
-Receptor on TCell that is up-regulated by dendritic cells during an inflammation response in order to receive chemotaxis signals to recruit lymphocytes to the the lymphoid tissues for activation
What happens to periphery dendritic cells when they are activated
1) They up regulate the production of CCR7 and increase their expression for CD80 and MHC/HLA complexes
2) Travel to lymph tissue to present Ag to T-cells, maturing along the way
TCR (Location, Function; Ligand, Ligand Location)
T cell receptor; On T-lymphocyte; Recognizes the antigen; MHC-I or II; All nucleated cells and APCs, respedctively
CD4/CD8 (Location, Function; Ligand, Ligand Location)
T-lymphoctes; signal transduction for immune response/proliferation; MHCI or II; All nucleated cells and APCs, respectively
CD28 (Location, Function; Ligand, Ligand Location)
T-Lymphocytes; costimulatory molecule during immune synapse; CD80 (B7); APCs
CD40 (Location, Function; Ligand, Ligand Location)
APC; costimulatory receptor during immune synapse; CD40 Ligand (CD40L); T-lymphocyte
CTLA-4 (Location, Function; Ligand, Ligand Location)
T-lymphocyte; inhibitory receptor to CD28; CD80 (B7); APCs
PD-1 (Location, Function; Ligand, Ligand Location)
T-lymphocyte; Inhibitory receptor; PDL-1; APCS, tumors, Tissue cells
L-selectin (Location, Function; Ligand, Ligand Location)
T-lymphocyte; weakly binds to HEV; L-selectin ligand; HEV
LFA-4 (Location, Function; Ligand, Ligand Location)
T-lymphocyte; strongly binds/stops t-lymphocyte movement on HEV; I-CAM; HEV
CCR7 (Location, Function; Ligand, Ligand Location)
T-lymphocyte; Recruits lymphocytes to lymph for activation - unregulated by dendritic cells; CCL-19, CCl21; HEV
What is S1P-receptor and it’s function
A receptor that gets bounds by CD69, inhibiting T-cells from leaving the lymph so they can 1) become functionally active and 2) proliferate enough B-cells
