T cell-Mediated Immunity Flashcards

1
Q

What is CCR7

A

-Receptor on TCell that is up-regulated by dendritic cells during an inflammation response in order to receive chemotaxis signals to recruit lymphocytes to the the lymphoid tissues for activation

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2
Q

What happens to periphery dendritic cells when they are activated

A

1) They up regulate the production of CCR7 and increase their expression for CD80 and MHC/HLA complexes
2) Travel to lymph tissue to present Ag to T-cells, maturing along the way

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3
Q

TCR (Location, Function; Ligand, Ligand Location)

A

T cell receptor; On T-lymphocyte; Recognizes the antigen; MHC-I or II; All nucleated cells and APCs, respedctively

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4
Q

CD4/CD8 (Location, Function; Ligand, Ligand Location)

A

T-lymphoctes; signal transduction for immune response/proliferation; MHCI or II; All nucleated cells and APCs, respectively

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5
Q

CD28 (Location, Function; Ligand, Ligand Location)

A

T-Lymphocytes; costimulatory molecule during immune synapse; CD80 (B7); APCs

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6
Q

CD40 (Location, Function; Ligand, Ligand Location)

A

APC; costimulatory receptor during immune synapse; CD40 Ligand (CD40L); T-lymphocyte

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7
Q

CTLA-4 (Location, Function; Ligand, Ligand Location)

A

T-lymphocyte; inhibitory receptor to CD28; CD80 (B7); APCs

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8
Q

PD-1 (Location, Function; Ligand, Ligand Location)

A

T-lymphocyte; Inhibitory receptor; PDL-1; APCS, tumors, Tissue cells

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9
Q

L-selectin (Location, Function; Ligand, Ligand Location)

A

T-lymphocyte; weakly binds to HEV; L-selectin ligand; HEV

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10
Q

LFA-4 (Location, Function; Ligand, Ligand Location)

A

T-lymphocyte; strongly binds/stops t-lymphocyte movement on HEV; I-CAM; HEV

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11
Q

CCR7 (Location, Function; Ligand, Ligand Location)

A

T-lymphocyte; Recruits lymphocytes to lymph for activation - unregulated by dendritic cells; CCL-19, CCl21; HEV

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12
Q

What is S1P-receptor and it’s function

A

A receptor that gets bounds by CD69, inhibiting T-cells from leaving the lymph so they can 1) become functionally active and 2) proliferate enough B-cells

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