Cytokines & Immune Regulators Flashcards
What are the cytokines produced by T-cells?
IL-2, IL-4, IL-5, IL-17, IL-17, IL-22, TGF-b, IFN-y
IL-2 (Function, Source)
proliferate T cells - CD25 makes high affinity ; activated T cell
Helps activate and proliferate CD8 When secreted by Th1
IL-4 (Function, Source)
Turns B-cell -> IgM antibody (B-cell proliferation); Th2 cells ; m2 macrophage proliferation
IL-5 (Function, Source)
up regulate eosinophils/Mast; Th2 cells, Mast
IL-17 (Function, Source)
increase acute inflammation; Th17, other cells
Antimicrobial activity is prime function
IL-22 (Function, Source)
maintain the endothelium barrier and serves antimicrobial function; Th17, NK cells
TGF-b (Function, Source)
inhibits T cell proliferation; T-Regs, M2 macrophages
IFN-y (Function, Source, Target)
1) Stimulates Th1 proliferation, CLASS II HLA and B7 (CD80) expression
2) Autocrine - activates Th1 and when secreted, either activates macrophages to kill or B-cells
3) Tfh cells - class switch their Abs/Complement binding (ACTIVATE B cell PROLIFERATION)
Also stimulates m1 macrophages when secreted by NK cells
IL-12 (Function/target, source)
1) (proliferates Th1 (during immunologic synapse binding) & activates NK cells
2) Secreted by activated APCs
IL-15 (Function/target, source)
1) Keeps Memory T-Cells alive
2) Secreted by phagocytes
IL-6
1) Proliferates Th17
2) Causes Fever, Acute phase response
IL-1
1) Proliferates Th17 ; inflammation response
2) Pro-inflammatory, Fever, Acute phase response
3) Secreted by activated macrophages (M1), neutrophils (DAMPS also increase production)
Vascular permeability
IL-17
- Secreted by Th17
- Proinflammatory, neutrophil response, antimicrobial
IL-22
- Secreted by Th17
- Proinflammatory, neutrophil response, antimicrobial, BARRIER PROTECTION
IL-13
M2 macrophage proliferation