Systemic Sclerosis treatment

Question 1

what drugs are given as first line treatment for Raynaud’s

Answer 1

calcium channel blockers, such as nifedipine

Question 2

what other drugs can be used to treat Raynaud’s

Answer 2

fluoxetine, ARBs, nitrates

Question 3

what drugs are used in Raynaud’s when there is a risk to tissue perfusion

Answer 3

PDE-5 inhibitor, prostacyclin infusion, endothelin receptor antagonist

Question 4

give an example of a PDE-5 inhibitor and a endothelin receptor antagonist

Answer 4

PDE-5 inhibitor = sildenafil

endothelin receptor antagonist = bosentan

Question 5

what treatment are used to treat pulmonary hypertension caused by vasculopathy

Answer 5

PDE-5 inhibitor, endothelin receptor antagonist, eproprostenol infusions, oxygen

Question 6

what drugs can be used to treat interstitial lung disease caused by systemic sclerosis

Answer 6

mycophenolate mofetil(immunosuppressant first line), rituximab(second line) and nintedanib(antifibrotic)

Question 7

what drugs are used in skin fibrosis treatment, which is rare

Answer 7

methotrexate, mycophenolate

immunosuppressants

Question 8

what is the treatment used for renal disease caused by systemic sclerosis

Answer 8

ACE inhibitors, and sometimes dialysis needed