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Rheumatology Medicine > Systemic Lupus Erythrmatosus > Flashcards

Systemic Lupus Erythrmatosus Flashcards

1
Q

What is SLE?

A

Multi-system autoimmune disease

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2
Q

What is the pathophysiology behind SLE?

A

Inadequate T cell suppressor activity with increased B cell activity

B cells secrete auto-antibodies

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3
Q

What gene is involved in SLE?

A

HLA D2

HLA D3

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4
Q

What environmental factors can bring on SLE?

A

UV light
Drugs
Infection

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5
Q

What is the pneumonic for symptoms?

A

SOAP BRAIN MD

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6
Q

What are the symptoms?

A

Serositis
Oral ulcers
Arthritis
Photosensitvity

Blood disorders - low WCC, lymphopenia, haemolytic anaemia
Renal involvement - glomerulonephritis
Auto-antibodies - ANA 
Immunology - low c3, c4
Neurologic disorder

Malar rash
Discoid rash

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7
Q

What is a malar rash?

A

Red rash across cheeks

- tends to spare nasolabial folds

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8
Q

What investigations do you do for suspected SLE?

A

Bloods

  • FBC
  • CRP
  • U+Es
  • ANA
  • anti - dsDNA
  • anti phospholipid antibodies
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9
Q

What is ANA?

A

Anti-nuclear antibody

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10
Q

What are the anti-phospholipid antibodies?

A

Anti-cardiolipin

Lupus anticoagulant

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11
Q

What is anti-phospholipid syndrome?

A

Presence of anti-phospholipid antibodies

  • either primary
  • or secondary to SLE
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12
Q

What is the risk of anti-phospholipid syndrome?

A

Coagulation deficit
Liverdo reticularis
Obstetric complications
Thrombocytopenia

CLOT

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13
Q

What is liverdo reticularis?

A

Mottled appearance of thighs

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14
Q

How is anti-phospholipid syndrome managed?

A

Aspirin

Warfarin

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15
Q

How is SLE managed?

A

Avoid sun
Screen for HTN, lipids, diabetes

Hydroxychloroquine
Methotrexate
Azathioprine

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16
Q

How is SLE managed acutely?

A

Steroids

17
Q

What is drug induced lupus?

A

Lupus induced by drugs

- resolves on stopping drug

18
Q

What antibody is involved with drug induced lupus?

A

Anti-histone antibody

19
Q

What drugs can cause drug induced lupus?

A

Isoniazid
Procainamide
Hydralazine
Phenytoin

20
Q

What are the symptoms of drug induced lupus?

A

Arthralgia
Myalgia
Skin problems

Rheumatology Medicine (17 decks)

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