Gout Flashcards
What is gout?
Inflammation of joint associated with hyperuricemia
Which joint is most commonly affected in gout?
1st metatarsophalangeal joint
What is the appearance of the crystals in gout?
Negative birefingent crystals
- needle shaped
What make up the crystals in gout?
Urate
What are the risk factors for gout?
Male Increased purine inrake High alcohol intake Obesity Hyertension Smoking
How is gout managed preventatively?
Maintain optimal weight
Regular exercise
Reduce alcohol
Diet modifcation
How is gout managed acutely?
NSAIDs
Colchicine
How does colchicine work?
Inhibits pro-inflammatory mechanisms
How is gout managed between flares?
Allopurinol
- lowers urate
Why is allopurinol not started in the acute phase?
Can worsen symptoms
What is pseudo gout?
Inflammation due to deposits of calcium pyrophosphate
What can cause pseudogout?
OA Hyperparathyroidism Haemochromatosis Acromegaly Wilson's disease
What is the x-ray change in pseudogout?
Chrondocalcinosis - soft tissue calcium deposition
What is the appearance of the crystals in pseudogout?
Positive birefringent
- rhomboid
What makes up the crystals in pseudogout?
Calcium pyrophosphate
