Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Rheumatology Medicine > Rheumatoid Arthritis > Flashcards

Rheumatoid Arthritis Flashcards

1
Q

What is RA?

A

Rheumatoid arthritis

Autoimmune condition which causes inflammation of the synovium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which joints are more commonly affected by RA?

A

Small joints

  • MCPs
  • PIPs
  • MTPs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the distribution of RA?

A

Bilateral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

When is RA worse?

A

Morning stiffness >30mins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What genes are associated with RA?

A

HLA DR1

HLA DR4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is a pannus?

A

Pannus is formed in RA when the inflammed synovium becomes hypertrophied

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are signs of RA?

A

Rheumatoid nodules
Swan neck deformity
Z thumb
Boutonniere deformity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are rheumatoid nodules?

A

Fibrinoid necrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is a swan neck deformity?

A

DIP flexion with PIP hyperextension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is a Boutonniere deformity?

A

PIP flexion with DIP hyperextension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the extra-articular manifestations of RA?

A

Carpal tunnel syndrome
Cardiac risk
Cord compression

Anaemia
Amyloidosis
Arteritis

Pericarditis
Pleural disease
Pulmonary disease

Sjogren’s
Sceleritis/episceleritis
Splenomegaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is Felty’s syndrome?

A

Triad of

  • RA
  • splenomegaly
  • neutropenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the difference between scleritis and episceleritis?

A

Sceleritis

  • red
  • deeper vessels
  • painful
  • risk of perforation

Episceleritis

  • shallower
  • less painful
  • red
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the diagnostic criteria for RA?

A

4 out of 7

  • morning stiffness >1hour
  • arthritis >3 joints
  • arthritis of hands
  • symmetrical
  • rheumatoid nodules
  • +RF
  • x-ray changes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the x-ray changes in RA?

A

Loss of joint space
Erosions (juxta-articular)
Soft tissue swelling
Subluxation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What causes juxta-articular erosions?

A

TNF-a stimulates osteoclast differentiation

Osteoclasts cleave bone

17
Q

What is the scoring system for RA management?

A

DAS-28

18
Q

What investigations would you do for suspected RA?

A 
FBC
CRP
ESR
Anti-CCP
RF
19
Q

Which antibody is better?

A

Anti-CCP

20
Q

How is RA managed?

A

DMARDs

  • methotrexate
  • sulfasalazine

Anti-TNF

  • infliximab
  • adalimub

Steroids

NSAIDs

21
Q

What is a side effect of methotrexate?

A

Myelosuppression

22
Q

What do you need to take with methotrexate?

A

Folic acid

Methotrexate = anti-folate

Rheumatology Medicine (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions