Syntometrine

Question 1

What is syntometrine?

Answer 1

• It is a Oxytocic - drugs that cause contraction of the uterus.
• combination of two hormones: Ergometrine and Oxytocin.

Question 2

What is Oxytocin?

Answer 2

Naturally occurring hormone released by the hypothalamus during uterine contraction as part of a positive feedback loop.

Question 3

What is ergometrine?

Answer 3

Synthesised drug compound with oxytocic effects.

Question 4

Pre-Hospital Indication

Answer 4

• Post partum haemorrhage following neonatal delivery with or without placental delivery

Question 5

Presentation

Answer 5

• Ampoule containing 500 micrograms 10mg/ml

- For IM Administration

Question 6

Pharmacological Action

Answer 6

• Stimulates Lactation

- Stimulates uterine contraction during pregnancy

Question 7

Pharmacodynamic Action

Answer 7

• Action is specific to uterine muscle
• Stimulates the uterine muscles to contract forcefully
• force and duration of the contraction is dose dependent

Question 8

Pharmacokinetic Action

Answer 8

• Naturally occurring oxytocin is released on stimulation from the hypothalamus with absorption and transportation by the vascular system (blood)
• IM administration reduces blood plasma concentration and offers gradual bioavailability
• internally metabolised

Question 9

Side Effects

Answer 9

• Hypertension and Bradycardia
• abdominal pain with contractions
• headache
• nausea and vomiting