Misoprostal Flashcards
Drug - Pharmacology
1
Q
What is misoprostal?
A
Prostaglandin Hormone
Prostaglandins stimulate peripheral nerve endings.
Normally licensed for gastric ulcers
2
Q
Pre-Hospital Indication
A
Postpartum hemorrhage following neonatal delivery with or without placental delivery.
• Miscarriage with life-threatening bleed.
• Hypertension (BP >140/90)
Where syntametrine use is unavailable or inappropriate
3
Q
Presentation
A
200microgram tablets
oral or PV administration
4
Q
Pharmacological Action
A
- Stimulates uterine contractions and minimises blood loss.
- Induced abortion (unlicensed indication)
5
Q
Pharmacodynamic Action
A
- Uterine muscle contraction
- ripens cervix
6
Q
Pharmacokinetic Action
A
- Absorption across cell membrane
- Transportation by vascular system
- oral administration offers gradual bioavailability
- metabolised in liver and excreted via kidneys in urine.
7
Q
Side Effects
A
- Abdominal pain with contractions
- Pyrexia
- nausea and vomiting
