Insulin

Question 1

What is Insulin

Answer 1

• Small protein consisting of 2 polypeptide chains

- stored as proinsulin in pancreatic islets-inactive hormone

Question 2

Action of insulin

Answer 2

• lowers blood glucose by facilitating uptake and utilization
• shifts metabolism of fats and proteins from breakdown to storage
• enhances oxidation of glucose and incorporation into storage molecules

Question 3

Insulin Binding to its receptor causes what?

Answer 3

Receptor activation - activates multiple kinases and phosphorylates that regulate metabolic activity.

Question 4

Insulin action in the liver

Answer 4

stimulates glycogen and fat synthesis and inhibits glycogen breakdown and ketone body formation

Question 5

Insulin action in muscle tissue

Answer 5

stimulates glucose and protein synthesis

Question 6

Insulin action in adipose tissue

Answer 6

inhibition of lipolysis and stimulates glucose uptake and triglyceride synthesis