Furosemide

Question 1

Other names

Answer 1

Lasix

Question 2

Class

Answer 2

Diuretic

Question 3

Classification

Answer 3

Loop Diuretic

Question 4

Actions

Answer 4

Increase volume of urine produced by Kidney

Question 5

What is a Diuretic?

Answer 5

Any chemical that increases urine volume output:

• caffeine (dilates afferent arteriole of kidney
• alcohol (inhibits ADH secretion)
• Lasix (inhibits Na+, K-, Cl- reabsorption at nephron loop
• Spironolactone (Aldosterone Antagonist)
• Amiloride (potassium sparing)

Question 6

Indication

Answer 6

• Diuretics used in pulmonary oedema secondary to cardiac failure (Left ventricular failure)
• Sometimes routinely prescribed to Manage resistant hypertension

Question 7

Presentation

Answer 7

• Ampoule containing 2ml or 5ml
• Furosemide at 10mg/ml
• Prefilled syringe
• May come in 40mg tablets or oral solution on prescription

Question 8

Pharmacological Action

Answer 8

• Increases renal blood flow
• 100% bioavailability IV vs 60-64% PO
• 2hr half life with 4-6hr effect

Question 9

What is its Pharmacological Action?

Answer 9

• Inhibits reabsorption of electrolytes (Na) back into blood stream
• reduction of circulating blood volume with excretion of electrolytes (including water) in urine
• Fluid is further drawn from cellular tissues so further reducing tissue oedema

Question 10

Side effects

Answer 10

• electrolyte imbalance
• hypokalaemia induced arrhythmias
• dehydration