Ipratropium bromide

Question 1

Class

Answer 1

Antimuscarinic

Question 2

Classification

Answer 2

Bronchodilator

Question 3

Actions

Answer 3

Short term of COPD and paediatric asthma

Question 4

Indication

Answer 4

• Acute asthma
• Severe or life threatening asthma
• COPD

Question 5

Presentation

Answer 5

• Inhalational
• Aerosol inhaler 20mcg/dose (+/- 200 doses in an inhaler)
• Nebuliser 250mcg/500mcg

Question 6

Pharmacological Action

Answer 6

• Parasympathetic system innervates cholinergic neurons. Muscarinic receptors are present in glands, cardiac and smooth airway muscle.
• reduced muscarinic action

Question 7

Pharmacological Action Figures

Answer 7

• Onset of action: 30 minutes
• peak effect: 60-90 mins
• Duration of action: 4-6 hours
• Ipratropium Bromide + Beta2 better synergistic effect
• works better in asthmatic patients on beta blockers

Question 8

Side effects

Answer 8

• dry mouth
• dry, flushed, hot skin
• mydriasis
• tachycardia/Arrhythmia
• Urine retention