Sympathomimetics

Question 0

Non-selective, direct acting, sympathomimetics

Answer 0

Epinephrine, norepinephrine, dopamine,

Question 1

MOA of sympathomimetics

Answer 1

Direct activation of adrenoceptors
Releases stored catecholamines
Inhibits catecholamines reuptake

Question 2

Epinephrine

Answer 2

Activates a and b receptors
a1 - vasoconstrictor increases BP by increasing TPR
b1 - increased HR, conduction, contractility
b2 - bronchodilator

Question 3

Norepinephrine

Answer 3

Activates a and b receptors
a1 - vasoconstrictor increases BP by increasing TPR
b1 - increased HR, conduction, contractility
b2 - bronchodilator

Question 4

Dopamine

Answer 4

Activates a and b and D receptors
a1 - vasoconstrictor increases BP
b1 - increased HR, conduction, contractility
D1 - vasodilation in splanchnic and renal vessels

Question 5

Low dose epinephrine 1-5 mcg

Answer 5

Renal/splanchnic vasodilation by D1 RECEPTORS

Question 6

Medium dose 5-15 mcg

Answer 6

Inotropic. Heart rate and cardiac contractility via BETA RECEPTORS

Question 7

High dose >15 mcg

Answer 7

Vasoconstrictor increased BP alpha receptors

Question 8

Sympathomimetics beta-non selective

Answer 8

Isoproterenol
Activates b receptors
b1 - increased HR, conduction, contractility
b2 - bronchodilator

Question 9

Selective alpha 1 antagonist

Answer 9

Phenylephrine/ pseudophedrine
a1 - vasoconstrictor, increases BP
WOF rebound nasal congestion
Mydriasis without psychoplegia

Question 10

Selective a2 agonist

Answer 10

Clonidine, methyldopa, apraclonidine

Question 11

Clonidine

Answer 11

a2 - decreases central sympathetic outflow

WOF for rebound hypertension give PHENTOLAMINE as antidote

Question 12

Methyldopa

Answer 12

a2 - decreases central sympathetic outflow esp. Pre-eclampsia
WOF hemolytic anemia (+) Coomb’s test

Question 13

Apraclonidine

Answer 13

a2 - decreases secretion of aqueous humor.

BRIMONIDINE

Question 14

Selective beta1 agonist

Answer 14

Dobutamine b1 - increases HR and contractility

Use in acute heart failure

Question 15

Selective b2 - agonist

Answer 15

Albuterol/salbutamol, terbutaline, ritodrine
Activates b2 receptors in bronchial smooth muscles, causes bronchodilation,
TR can be used for preterm labor

Question 16

Acute heart failure, septic shock

Answer 16

b1 and D1 agonist

to raise cardiac output

Question 17

Hemostasis, decongestant, spinal shock

Answer 17

a1 agonist

Causes vasoconstriction, temporary maintenance of BP

Question 18

Bronchospasm

Premature labor

Answer 18

b2 agonist,

bronchodilation and relaxation of uterine smooth muscle

Question 19

Hypertension

Glaucoma

Answer 19

a2 agonist

Decreases BP