Antiarrhythmics

Question 0

Class 1 antiarrhythmic

Answer 0

Has local anesthetic activity

Acts on phase 0 of cardiac action potential

Question 1

Singh-Vaughan Williams classification

Answer 1

Class 1 sodium channel blockers
Class 2 beta blockers
Class 3 potassium channel blockers
Class 4 calcium channel blockers

Question 2

Class 1a

Answer 2

Prolongs AP duration

Question 3

Class 1b

Answer 3

Shortens AP duration

Question 4

Group 1c

Answer 4

no effect on AP

Question 5

MOA group 1

Answer 5

Block conduction in ischemic and depolarized cells.

Slows down or abolishes abnormal pacemakers

Question 6

Most selective class 1 group to ischemic tissue

Answer 6

Class 1b

Question 7

Use dependent for class 1

Answer 7

Selective for tissues that are frequently depolarizing.

Question 8

State dependent class1 antiarrhythmic

Answer 8

Selective for tissues that are relatively depolarized during rest

Question 9

Class 1a drugs

Answer 9

Procainamide, disopyramide, quinidine

I Am the Quin who PROClaimed DISO’s pyramide

Question 10

Procainamide

Answer 10

Blocks Ina and some Ik channels.
Slowed conduction velocity and pacemaker activity.
Post MI arrhythmia
WOF lupus like syndrome

Question 11

Disopyramide

Answer 11

Marked antimuscarinic effects.

Atropine like effects

Question 12

Quinidine

Answer 12

Can be used in malaria.

WOF cinchonism - headache, vertigo, tinnitus

Question 13

Class 1b antiarrhythmic drugs

Answer 13

I Buy MEXIcan TOCAs from LIly

Mexiletine, tocainide, lidocaine

Question 14

Ib selective for

Answer 14

Ischemic or depolarized Purkinje and ventricular tissue.

Question 15

Lidocaine

Answer 15

Mexiletine, tocainide, phenytoin
DOC for ventricular arrhythmias post MI. or digoxin induced arrhythmia.
Lidocaine is the least cardiotoxic

Question 16

Drugs causing agranulocytosis

Answer 16

CCCAPPIT!!!

Clozapine, Co-trimoxazole, Colchicine, Aminopryrine, Phenylbutazone, PTU, Indomethacin, Tocainide

Question 17

Class 1c drugs

Answer 17

Flecainide, propafenone, encainide, moricizine
Used for refractory arrhythmias
CONTRAINDICATED post MI

Question 18

WPW

Answer 18

Procainamide and Amiodarone

Class 1a

Question 19

Class2 antiarrhythmic

Answer 19

Beta blockers reduces cAMP
reduction of both na and ca channels
Prolonged PR intervals
Acts on phase 4

Question 20

ESMOLOL

Answer 20

SVT

Question 21

Class 2 with class 3 properties

Answer 21

Sotalol

Question 22

Thyrotoxic arrhythmias

Answer 22

ESMOLOL

Question 23

Class 3

Answer 23

Acts on phase 3.
Prolongs AP duration.blocks potassium no repolarization
Increase QT Interval

Question 24

Class 3 drugs

Answer 24

Dofetilide, sotalol, Amiodarone, ibutilide

AIDS

Question 25

Dofetilide and ibutilide

Answer 25

WOF torsades de pointes

Question 26

Sotalol

Answer 26

WOF sinus Brady, asthma

Question 27

Amiodarone/ dronedarone

Answer 27

Marked prolonged AP and RP.
Off label refractory arrhythmias. Most efficacious.
WOF microcrystalline deposits in cornea and skin

Question 28

Amiodarone toxicity

Answer 28

Pulmonary fibrosis, Paresthesia, Tremor, Thyroid dysfunction, Corneal deposits, Skin deposits

Question 29

Class 4 drugs

Answer 29

Verapamil, diltiazem
Calcium dependent like AV node
Increased PR interval can use in SVT
NON-DIHYDROPYRIDINE

Question 30

Adenosine

Answer 30

Increase diastolic Ik of AV Node

DOC paroxysmal SVT