Adrenergic Pharmacology

Question 0

Tyrosine –> levodopa by tyrosine hydroxylase inhibited by

Answer 0

Metyrosine

Then levodopa decarboxylated to dopamine and hydroxylated to norepinephrine

Question 1

Norepinephrine is the primary neurotransmitter at the sympathetic postganglionic neuron- effector cell synapses except in

Answer 1

Eccrine sweat glands

Vasodilator sympathetic fibers in skeletal muscle

Question 2

Storage of NE

Answer 2

Reserpine Inhibits vesicular transport

MAOIS increase stores of NE and dopamine

Question 3

Calcium enters interacts with SNARE inhibited by

Answer 3

Guanethedine

Promoted by amphetamines and tyramine

Question 4

Termination via reuptake via NET DAT

Answer 4

Inhibited by cacaine and TCAs

Question 5

Termination by metabolizing into metanephrines and VMA

Answer 5

Inhibited by MAOIs and COMTis

Question 6

Synthesis inhibitors

Cholinergic-adrenergic

Answer 6

HEMICHOLINIUM - Metyrosine

Question 7

Storage inhibitors

Cholinergic-adrenergic

Answer 7

VESAMICOL - Reserpine

Question 8

Release inhibitors

Cholinergic-adrenergic

Answer 8

Botulinum - guanethidine

Question 9

Reuptake inhibitors

Cholinergic-adrenergic

Answer 9

Metabolism neostigmine - MAOIs and COMTis

Reuptake - none - cocaine TCA

Question 10

Adrenoceptors

Answer 10

a1 - smooth muscle constriction
a2 - nerve endings and smooth muscles
b1 - heart and JGA
b2 - smooth muscle dilation, lungs

Question 11

Miscellaneous adrenoceptors

Answer 11

b3 - fat cells stimulates lipolysis
D1 - renal and splanchnic
D2 - inhibits adenylyl cyclase in nerve terminals