Heart Failure Treatment Flashcards
Left sided heart failure
Orthopnea, PND, Pulmonary congestion
Digoxin
Cardiac glycoside.
Inhibits nakatpase. Increases intercellular calcium, increases cardiac contractility
Right sided heart failure
Hepatomagaly, edema, engorged neck veins
Digoxin side effects
Narrow therapeutic window. Causes visual changes yellow halos
Drugs with a narrow therapeutic index.
WALA na Cyang PaPa! VasTeD na!
Warfarin, aminoglycosides, lithium, amphotericin b, carbamazepine, Phenobarbital, phenytoin, Vancomycin, Theophylline, Digoxin
Digitalis toxicity
Exacerbated by hypokalemia, hypomagnesemia, and hypercalcemia.
Arrythmogenesis
Treatment of digitalis toxicity
Correct electrolyte imbalance
Lidocaine as antiarrhythmic
Fab fragments Digibind
Diuretics
Furosemide for immediate reduction of pulmonary edema,
Spirinolactone and eplerenone
Angiotensin antagonist
Reduce aldosterone secretion
Decrease ventricular remodeling cardioprotective
Beta1 selective sympathomimetic
Dobutamine and dopamine for acute heart failure
Beta blocker
Carvedilol, labetalol, metoprolol, reduces progression of chronic HF
Phosphodiesterase inhibitors
Inamrinone, milirinone,
Increases cAMP, Intrecellular calcium causes vasodilation
Survival in CHF
ABA! Buhay ka pa!
ACEIs
Beta blocker
Aldosterone antagonist
Hydralazine and isosorbide dinitrate
Shown to reduce mortality in African Americans
Nitroprusside, nitroglycerin
Increases afterload