Sympatholytics

Question 1

Sympatholytics can be

Answer 1

Receptor selective or non-selective, full antagonists or partial, reversible or irreversible

Question 2

Sympatholytics primarily cover two classes of drugs

Answer 2

beta blockers and alpha blockers

Question 3

Alpha blockers include

Answer 3

Phentolamine (regitine), Doxazosin (cardura), prazosin (minipres), Tterazosin (hytrin), Tamsulosin (flomax), Silodosin (Rapaflo), Alfuzosin (uroxatral)

Question 4

B1 selective blockers include

Answer 4

acebutolol (sectral), Atenolol (tenormin), bisoprolol (zabeta), esmolol (brevibloc), Metoprolol (lopressor, Toprol), Nebivolol (bystolic)

Question 5

B1 nonselective blockers include

Answer 5

carvedilol (coreg), labetolol (normodyne), nadolol (Corgard), propranolol (Inderal), Sotalol (Betapace)

Question 6

B1 nonselective blockers include

Answer 6

carvedilol (coreg), labetolol (normodyne), nadolol (Corgard), propranolol (Inderal), Sotalol (Betapace)

Question 7

Phentolamine (regitine)

Answer 7

alpha, only non-selective alpha blocker, IV, short acting, vasodilator, induced tachycardia (problem),

Question 8

Doxazosin (cardura)

Answer 8

vasodilator, alpha1, hypertension, also BPH*, 20 hour half life, once daily, most common, dose titration necessary

Question 9

Terazosin (hytrin)

Answer 9

vasodilator, alpha1, hypertension, also BPH*, 12 hour half life, dose titration necessary

Question 10

Prazosin (minipres)

Answer 10

vasodilator, alpha1, hypertension, also BPH*, 3 hour half life, once daily, dose titration necessary

Question 11

What carries risk for exacperating BPH

Answer 11

benztropine

Question 12

Alfuzosin (Uroxatral)

Answer 12

uroselective a1, limited use, orthostatic HTN

Question 13

Tamsulosin (Flomax)

Answer 13

a1, BPH, no dose adjust, no dose titration

Question 14

Silodosin (Rapaflo)

Answer 14

a1, adjust renal, BPH, me too, $$$$

Question 15

Ergot alkaloids

Answer 15

old, a1, LSD derivative, migraines, not clean, can induce labor, limited use

Question 16

One of the most well studied and used drug class?

Answer 16

beta blockers

Question 17

uses of beta blockers

Answer 17

HTN, CHF, MI, migraines, arrythmias, CAD, glaucoma, stage fright, PTSD, tremor, etc

Question 18

Beta blocker info

Answer 18

competative antagonist, non-selective, or cardioselective, impact on renin release, variable lipid solubility, can act as partial agonist

Question 19

Well-known ADR of beta blockers

Answer 19

bradycardia, AV blockade, compromised CO, masks symptoms of hypoglycemia, tachy

Question 20

Well-known ADR of beta blockers

Answer 20

bradycardia, AV blockade, compromised CO, masks symptoms of hypoglycemia, tachy

Question 21

Propranolol (Inderal)

Answer 21

non selective B1, B2, short acting, lipophiilic, DOC for stage fright, migraine, PTSD, and variceal bleeding, old, cheap

Question 22

Nadolol (Corgard)

Answer 22

nonselective B1, B2, longer acting, no niche

Question 23

Sotalol (betapace)

Answer 23

non-selective B1, B2, arrythymias, must adjust renal, only used when necessary because of adrs

Question 24

Labetalol (Normodyne)

Answer 24

non-slective a1, B1. B2, acute HTN emergency, vasodilation (a1), little ADR but ortho hypotension, DOC for HTN w/ acute ischemic stroke and pregnant/ labor

Question 25

Carvedilol (coreg)

Answer 25

non-slective a1, B1, B2, CHF, slow progression of disease by acting on RAAS

Question 26

Metoprolol (lopressor, toprol)

Answer 26

succinate (toprol): long acting, tartrate (lopressor) short acting; selective B1, CHF, most common beta blocker

Question 27

Atenolol (tenormin)

Answer 27

selective B1, longer acting, no evidence to support CHF

Question 28

Bisoprolol (zebeta)

Answer 28

Selective B1, some use with CHF, not much