Other anterior pituitary hormones

Question 1

Glucocorticoids

Answer 1

cortisol, involved in normal metabolism and response to stress

Question 2

Mineralcorticoids

Answer 2

aldosterone, responsible for maintaining salt and water metabolism

Question 3

Glucocorticoid effects

Answer 3

promote normal intermediary metabolism, increase resistance to stress, alter blood cell levels in plasma, anti-inflammatory action

Question 4

What are the uses of glucocorticoid use?

Answer 4

replacement therapy for adrenocortical insufficiency, diagnose, cushings, replacement therapy for congenital adrenal hyperplasia, relief of inflammatoy sx, treat allergies, accelerate lung maturation

Question 5

Mineralcorticoid effects

Answer 5

aldosterone acts on kidney tubules/collecting ducts, inc reabsorption of sodium, bicarb, and h2o, dec reabsorption of K

Question 6

What does spironolactone do?

Answer 6

inhibits sodium reabsorption in the kidney, used to treat hyperaldosteronism, also for HTN, and can antagonize aldosterone and testosterone synthesis

Question 7

the release of growth hormone

Answer 7

highest level during sleep, release decrease with increasing age, decrease lean muscle, promotes cell proliferation and bone growth

Question 8

Uses of somatotropin

Answer 8

GH deficiency or growth failure in children, AIDs wasting syndrome, short bowel syndrome, replacement in adults with confirmed GH deficiency, illegal use as performance enhancing drugs

Question 9

GnRH drugs

Answer 9

leuprolide (Lupron), Goserelin (Zoladex)

Question 10

MOA of gonadotropin releasing hormone

Answer 10

agonist at GnRH receptor-suppress production of gonadal hormones when given continuously

Question 11

Clinical use of gonadotropin releasing hormone

Answer 11

treatment of prostatic cancer, endometriosis and precocious puberty, prostate cancer, breast cancer, endometriosis

Question 12

Male gonadotropins

Answer 12

testosterone, androstenedione, dihydrotestosterone

Question 13

female gonadotropins

Answer 13

estradiol, estriol, estrone, progesterone

Question 14

Oxytocin (Pitocin) MOA

Answer 14

stimulates uterine contractions, induce or reinforce labor, sensitivity of uterus to oxytocin increases with duration of pregnancy

Question 15

Oxytocin adrs

Answer 15

hn, uterine rupture, water retention and fetal death, contraindicated in abnormal fetal presentation, fetal distress and premature birth

Question 16

Vasopressin MOA

Answer 16

binds V2 receptor in kidney- increase water permeability and reabsorption, binds V1 receptor- vasoconstriction, inotropic stimulation

Question 17

When would V2 binding be necessary

Answer 17

diabetes insipidus

Question 18

toxicities of vasopressin

Answer 18

H2O intoxication and hyponatremia, headache, bronchoconstriction and tremor

Question 19

Desmopressin pearls

Answer 19

modified vasopressin, minimal V1 activity, preferred for diabetes insipidus and nocturnal enuresis, intranasal or oral administration, intranasal not for nocturnal enuresis