Non opiods Flashcards
Endorphins, enkephalins
provide a natural amount of pain relief
Norepinephrine, serotonin
play an inhibitory role in the descending tract, explains why antidepressants can be used for pain control
glutamate, GABA
several receptor provide many targets for combo therapy for pain control
Somatic pain
constant, well localized, aching, throbbing; analgesic, nerve block
Visceral pain
diffuse, deep, dull, cramping, squeezing, referred, analgesic, neurological procedures
neuropathic pain
altered sensations, stabbing, burned, constant or intermittent, sharp, shooting, antidepressant, anticonvulsants, neurological procedures, not opioids
types of chronic pain
pain that persists beyond expected healing time, related to chronic disease, w/out an identifiable cause, , chronic+acute associated with CA
Tolerance
reduced effect w/ same dose, need to increase dose to get same effect, not addiction
Pseudotolerance
a need to increase the dose, but only because of disease progression, new source of pain, drug interaction
Physical dependance
described as the occurence of withdrawal symptoms when the opioid is stopped all at once or without proper tapering
Addiction
a psychologically dependent state, they exhibit drug seeking behavior, compulsive use for their psychic effects
Pseudoaddiction
can present as addiction, but is a function of poorly controlled pain, once adequately controlled, their drug seeding tendencies disappear
Non-pharmacological approaches to pain pain control
remove source, psychotherapy, weight reduction, surgery, behavioral modification, rest/exercise, nerve block, massage therapy, acupuncture, hypnosis, heat, ice, pt
NSAIDs MOA
inhibition of the enzyme COX which prevents prostaglandin synthesis
Do NSAIDs produce tolerance
they do not tolerance, physical dependence, or psychological dependence
Ceiling effects of NSAIDs
analgesia has ceiling effect, less of ceiling effect to anti-inflammatory response, increased doses will still provide additional results
Popular NSAIDs
Diclofenac ER (Voltaren), Ibuprofen (Motrin, Advil), Naproxin (Naprosyn), Noproxen Sodium (Aleve, Anaprox), Meloxicam (Mobic), Indomethacin (Indocin), Ketorolac (Toradol)
Less popular NSAIDs
Etodolac (Lodine), Sulindac (Clinoril), Tometin (Tolectin), Oxaprozin (Daypro), Ketoprofen (Orudis), Piroxicam (Feldene), Nabumetone (Relafen)
NSAID characteristics that distinguish them from narcotics
antipyretic, anti-inflammatory, ceiling effect to analgesia, do NOT cause tolerance, do NOT cause physical or psychological dependence, potentcy, time of onset, duration of action
NSAID clinical uses
acute pain of skeletal muscle or dental pain, pain and inflammation associated with osteoarthritis and RA, chronic malignaant pain as an addititve affect to narcotic analgestics, pain related to bone metastases